{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:59:27Z","timestamp":1792695567118,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["FWF P23797"],"award-info":[{"award-number":["FWF P23797"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Inflammation\u2010related diseases are a worldwide problem. The counteraction of inflammation with compounds activating the trigeminal nerve is one strategy to fight these diseases. Known trigeminally active compounds found in black or red pepper are the tingling <jats:italic>t\u2010<\/jats:italic>pellitorine, the pungent capsaicin, and the less pungent nonivamide. The presented study compares the anti\u2010inflammatory potential of nonivamide to the two known anti\u2010inflammatory compounds, elucidating the mechanism of action and the role of transient receptor protein (TRP) channels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Primary peripheral blood mononuclear cells (PBMCs) and U\u2010937 macrophages were stimulated with 1 \u03bcg\/mL LPS from <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>EC<\/jats:italic>\u2010LPS) to induce inflammation. Nonivamide attenuated the <jats:italic>EC<\/jats:italic>\u2010LPS induced release of IL\u20106 and TNF\u2010\u03b1 in PBMCs and U\u2010937 macrophages determined by magnetic bead kit analysis. This anti\u2010inflammatory mechanism was independent from nuclear factor\u2010kappa B pathway but mitogen\u2010activated protein kinase (MAPK) pathway may be involved. In addition, cotreatment of U\u2010937 with the trigeminally active compound and an antagonist of TRPV1 or TRPA1 abolished the anti\u2010inflammatory activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nonivamide possessed similar anti\u2010inflammatory potential as capsaicin and <jats:italic>t\u2010<\/jats:italic>pellitorine. In U\u2010937 macrophages, the tested compounds exploited an anti\u2010inflammatory effect by inhibiting the <jats:italic>EC\u2010<\/jats:italic>LPS induced activation of the MAPK pathway. In addition, the TRP channel activation plays a role in the anti\u2010inflammatory capacity of capsaicin and nonivamide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600474","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T08:16:47Z","timestamp":1474877807000},"source":"Crossref","is-referenced-by-count":41,"title":["Nonivamide, a capsaicin analogue, exhibits anti\u2010inflammatory properties in peripheral blood mononuclear cells and U\u2010937 macrophages"],"prefix":"10.1002","volume":"61","author":[{"given":"Jessica","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, Christian Doppler Laboratory for Bioactive Aroma Compounds University of Vienna Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob P.","family":"Ley","sequence":"additional","affiliation":[{"name":"Symrise AG  Holzminden 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