{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:06:56Z","timestamp":1788318416418,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["16182MFD416"],"award-info":[{"award-number":["16182MFD416"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>This study was designed to determine whether irisolidone and its glycoside kakkalide, which are the major constituents of the flower of <jats:italic>Pueraria lobata<\/jats:italic> (Kudzu) can attenuate ethanol\u2010induced gastritic injury in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Irisolidone and kakkalide inhibited IL\u20108 secretion and NF\u2010\u03baB activation in lipopolysaccharide\u2010stimulated KATO III cells. Therefore, we investigated their protective effects against ethanol\u2010induced gastric injury in mice. Pretreatment with kakkalide or irisolidone decreased the area of hemorrhagic ulcerative lesions caused by ethanol and suppressed stomach myeloperoxidase activity, CXCL4 secretion, and NF\u2010\u03baB activation. The ameliorating effect of irisolidone was more potent than that of kakkalide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Irisolidone may attenuate ethanol\u2010induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL\u20104 or IL\u20108 secretion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600517","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T09:33:03Z","timestamp":1471858383000},"source":"Crossref","is-referenced-by-count":14,"title":["Irisolidone attenuates ethanol\u2010induced gastric injury in mice by inhibiting the infiltration of neutrophils"],"prefix":"10.1002","volume":"61","author":[{"given":"Geum\u2010Dan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy Kyung Hee University  Dongdaemun\u2010gu Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy Kyung Hee University  Dongdaemun\u2010gu Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Eun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Kyung Hee University  Dongdaemun\u2010gu Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Joo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Kyung Hee University  Dongdaemun\u2010gu Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy Kyung Hee University  Dongdaemun\u2010gu Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090167"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00103.2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0715"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90232.2008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21010064"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.110.8_604"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.10.085"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-11499"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1965"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1202"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.531"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.114322"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.93.331"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9240-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.95.11_1283"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.93.9_1201"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05333.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.04.021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(02)00206-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000020490.34220.6d"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.03.027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071762"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9531-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400820"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05714.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.52.274"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2013.770521"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1996.0195"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(05)80025-3"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12263"}],"container-title":["Molecular Nutrition &amp; 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