{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:59:43Z","timestamp":1788850783368,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271923"],"award-info":[{"award-number":["31271923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471607"],"award-info":[{"award-number":["31471607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Exhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Exhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16\u2010day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short\u2010chain fatty acids (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Together, our findings suggest that NAT may protect mice against intense exercise\u2010induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201600585","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T10:33:47Z","timestamp":1484303627000},"source":"Crossref","is-referenced-by-count":88,"title":["Neoagarotetraose protects mice against intense exercise\u2010induced fatigue damage by modulating gut microbial composition and function"],"prefix":"10.1002","volume":"61","author":[{"given":"Na","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhao","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Li","sequence":"additional","affiliation":[{"name":"Animal Genomics and Improvement Laboratory United States Department of Agriculture Agriculture Research Service (USDA\u2010ARS)  Beltsville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enling","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhu","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjuan","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18839"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.435"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6104191"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306541"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307305"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.113"},{"key":"e_1_2_9_8_1","first-page":"70","article-title":"The microbiota: an exercise immunology perspective","volume":"21","author":"Bermon S.","year":"2015","journal-title":"Exerc. 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