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Chicoric acid has beneficial effects on obesity and liver injury, but its effects on nonalcoholic steatohepatitis (NASH) have not yet been determined. This study examined the effects of <jats:italic>Crepidiastrum denticulatum<\/jats:italic> extract (CDE) and its active compound chicoric acid in a mouse model of NASH and fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CDE and chicoric acid were orally administrated to mice fed a methionine\u2010 and choline\u2010deficient (MCD) diet. HepG2 and AML\u201012 cells in MCD medium were incubated with chicoric acid. MCD\u2010fed mice developed the histopathological characteristics of human NASH, including altered regulation of lipid metabolism, inflammation, fibrosis, and oxidation\u2010associated expression, along with augmented lipoperoxidation. Administration of CDE or chicoric acid to MCD\u2010fed mice and HepG2 and AML\u201012 cells in MCD medium reduced oxidative stress by upregulating antioxidant enzymes and decreased inflammation by inhibiting proinflammatory cytokines and nuclear factor\u2010\u03baB activation. In addition, CDE or chicoric acid reduced fibrosis, apoptosis, and lipogenesis\u2010related gene expression and increased AMP Kinase activation both in vivo and in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CDE and chicoric acid may be effective in the treatment of NAFLD and NASH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600632","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T14:34:35Z","timestamp":1481985275000},"source":"Crossref","is-referenced-by-count":44,"title":["Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency"],"prefix":"10.1002","volume":"61","author":[{"given":"Myungsuk","family":"Kim","sequence":"first","affiliation":[{"name":"Natural Products Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Convergence Research Center for Smart Farm Solution Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GyHye","family":"Yoo","sequence":"additional","affiliation":[{"name":"Natural Products Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Convergence Research Center for Smart Farm Solution Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Randy","sequence":"additional","affiliation":[{"name":"Natural Products Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Department of Biological Chemistry, Korea University of Science and Technology  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Convergence Research Center for Smart Farm Solution Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu Won","family":"Nho","sequence":"additional","affiliation":[{"name":"Natural Products Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"},{"name":"Convergence Research Center for Smart Farm Solution Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091978"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26672"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.876992"},{"key":"e_1_2_8_7_1","first-page":"4835","article-title":"Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options","volume":"9","author":"Sandra M.","year":"2015","journal-title":"Drug Des. 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