{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:29:10Z","timestamp":1773469750956,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Dietary fat content (low versus high fat) may modulate the serum lipid\u2010lowering effect of high\u2010performance (HP)\u2010inulin. This study investigated the effect of dietary HP\u2010inulin on metabolism in rats fed a low\u2010 or high\u2010fat diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Rats were fed a diet of 5% fat with 5% cellulose or 5% HP\u2010inulin (average degree of polymerization = 24) (low\u2010fat diet) or of 20% fat with 5% cellulose or 5% HP\u2010inulin (high\u2010fat diet) for 28 days. Total, HDL, and non\u2010HDL cholesterols, and triglyceride concentrations in the serum were measured along with total lipid content of liver and feces. Hepatic triglyceride and cholesterol, and fecal neutral and acidic sterol concentrations in total lipid were assessed. In addition, cecum SCFA levels and bacterial profiles were determined. The hypolipidemic effect of HP\u2010inulin differed depending on dietary fat content (5% versus 20%). Specifically, 5% inulin instead of cellulose in a semi\u2010purified diet significantly reduced serum lipid levels in rats fed a high\u2010fat diet, which was strongly associated with increased total lipid and neutral sterol excretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dietary fat content modulates the hypolipidemic effect of dietary inulin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600635","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T13:42:00Z","timestamp":1490794920000},"source":"Crossref","is-referenced-by-count":17,"title":["Dietary fat content modulates the hypolipidemic effect of dietary inulin in rats"],"prefix":"10.1002","volume":"61","author":[{"given":"Kyu\u2010Ho","family":"Han","sequence":"first","affiliation":[{"name":"Department of Food Science Obihiro University of Agriculture and Veterinary Medicine  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Food Science Obihiro University of Agriculture and Veterinary Medicine  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010ichiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Food Science Obihiro University of Agriculture and Veterinary Medicine  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Research Center Nippon Beet Sugar MFG Co.  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