{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:24Z","timestamp":1753869744166,"version":"3.41.2"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/G007993\/1"],"award-info":[{"award-number":["BB\/G007993\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The \u2018Predictive Adaptive Response\u2019 hypothesis suggests that the in utero environment when mismatched with the post\u2010natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes regulated via epigenetic mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In a 2 \u00d7 2 factorial design, female C57Bl\/6 mice were randomised to low or normal folate diets (0.4 mg\/2 mg folic acid\/kg diet) prior to and during pregnancy and lactation with offspring randomised to high\u2010 or low\u2010fat diets at weaning. Genome\u2010wide gene expression and promoter DNA methylation were measured using microarrays in adult male livers. Maternal folate depletion and high fat intake post\u2010weaning influenced gene expression (1859 and 1532 genes, respectively) and promoter DNA methylation (201 and 324 loci, respectively) but changes in expression and methylation were poorly matched for both dietary interventions. Expression of 642 genes was altered in response to both maternal folate depletion and post\u2010weaning high fat feeding, treatments imposed separately. In addition, there was evidence that the combined dietary insult (i.e. maternal folate depletion followed by high fat post\u2010weaning) caused the largest expression change for most genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our observations align with, and provide evidence in support of, a potential underlying mechanism for the \u2018Predictive Adaptive Response\u2019 hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600713","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T07:22:37Z","timestamp":1481181757000},"source":"Crossref","is-referenced-by-count":8,"title":["Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring"],"prefix":"10.1002","volume":"61","author":[{"given":"Jill A.","family":"McKay","sequence":"first","affiliation":[{"name":"Human Nutrition Research Centre Institute for Health and Society Newcastle University  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Human Nutrition Research Centre, Institute of Cellular Medicine Newcastle University  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Adriaens","sequence":"additional","affiliation":[{"name":"Maastricht Centre for Systems Biology  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris T.","family":"Evelo","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics \u2013 BiGCaT Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Ford","sequence":"additional","affiliation":[{"name":"Human Nutrition Research Centre, Institute for Cell and Molecular Biosciences Newcastle University  UK"},{"name":"Faculty of Health and Life Sciences Northumbria University  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Mathers","sequence":"additional","affiliation":[{"name":"Human Nutrition Research Centre, Institute of Cellular Medicine Newcastle University  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2004.1518"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02725"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082311"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2004.03.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000135998.08025.FB"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095292"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10040"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.4.888"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq028"},{"key":"e_1_2_12_11_1","first-page":"Cd007950","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","author":"De\u2010Regil L. 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