{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:52:49Z","timestamp":1763977969909,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Coordination Project of Innovation in Shaanxi province","award":["NO. 2014KTCL02-07"],"award-info":[{"award-number":["NO. 2014KTCL02-07"]}]},{"name":"Scientific Startup Funds for Doctors of Northwest A&F University","award":["Z109021611"],"award-info":[{"award-number":["Z109021611"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The aim of the present study was to investigate the inhibitory effects of sesamol, a phenolic lignan from sesame, on the systemic inflammation\u2010induced neuroinflammation and amyloidogenesis as well as memory impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6J mice were treated with 0.05% sesamol (w\/v) in the drinking water for 7 weeks, and then the mice were treated by intraperitoneal injection of LPS (0.25 mg\/kg) for 9 days. Sesamol supplementation significantly improved (by 36.9%) LPS\u2010induced decreased spontaneous alteration in Y\u2010maze test, as well as significantly restored LPS\u2010elicited mice cognitive deficits through restoring performances such as escape distance in Morris water maze test. Moreover, sesamol prevented LPS\u2010induced increases in A\u03b2<jats:sub>1\u201042<\/jats:sub> formation, levels of amyloid precursor protein, and neuronal \u03b2\u2010secretase 1 (BACE1) in the brain. Sesamol reduced LPS\u2010induced glial over\u2010activation by inhibiting MAPK and NF\u03baB pathway as well as expressions of inflammatory mediators such as IL\u20101\u03b2 and TNF\u03b1. Furthermore, LPS\u2010induced transcriptional factor NF\u03baB DNA binding activity was also inhibited by sesamol as examined by the electrophoretic mobility shift assay and molecular modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicated that sesamol mitigated LPS\u2010induced amyloidogenesis and memory impairment via inhibiting NF\u03baB signal pathway, suggesting that the compound might be plausible therapeutic intervention for neuroinflammation\u2010related diseases such as AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600734","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T17:51:25Z","timestamp":1479318685000},"source":"Crossref","is-referenced-by-count":37,"title":["Sesamol supplementation prevents systemic inflammation\u2010induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB"],"prefix":"10.1002","volume":"61","author":[{"given":"Zhigang","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglian","family":"Qiao","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70065-7"},{"key":"e_1_2_8_4_1","first-page":"803701","article-title":"The neuroinflammatory response in ALS: the roles of microglia and T cells","volume":"8","author":"Lewis C.\u2010A.","year":"2012","journal-title":"Neurol. 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