{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:37:13Z","timestamp":1784673433600,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural National Institutes of Health funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>\u03b1\u2010Cyclodextrin (\u03b1\u2010CD), a cyclic polymer of glucose, has been shown to lower plasma cholesterol in animals and humans; however, its effect on atherosclerosis has not been previously described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>apoE\u2010knockout mice were fed either low\u2010fat diet (LFD; 5.2% fat, w\/w), or Western high fat diet (21.2% fat) containing either no additions (WD), 1.5% \u03b1\u2010CD (WDA); 1.5% \u03b2\u2010CD (WDB); or 1.5% oligofructose\u2010enriched inulin (WDI). Although plasma lipids were similar after 11 weeks on the WD vs. WDA diets, aortic atherosclerotic lesions were 65% less in mice on WDA compared to WD (<jats:italic>P<\/jats:italic> &lt; 0.05), and similar to mice fed the LFD. No effect on atherosclerosis was observed for the other WD supplemented diets. By RNA\u2010seq analysis of 16S rRNA, addition of \u03b1\u2010CD to the WD resulted in significantly decreased cecal bacterial counts in genera <jats:italic>Clostridium<\/jats:italic> and <jats:italic>Turicibacterium<\/jats:italic>, and significantly increased <jats:italic>Dehalobacteriaceae<\/jats:italic>. At family level, <jats:italic>Comamonadaceae<\/jats:italic> significantly increased and <jats:italic>Peptostreptococcaceae<\/jats:italic> showed a negative trend. Several of these bacterial count changes correlated negatively with % atherosclerotic lesion and were associated with increased cecum weight and decreased plasma cholesterol levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Addition of \u03b1\u2010CD to the diet of apoE\u2010knockout mice decreases atherosclerosis and is associated with changes in the gut flora.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600804","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T18:34:25Z","timestamp":1484850865000},"source":"Crossref","is-referenced-by-count":39,"title":["Dietary \u03b1\u2010cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E\u2010deficient mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Toshihiro","family":"Sakurai","sequence":"first","affiliation":[{"name":"Lipoprotein Metabolism Section Cardio\u2010Pulmonary Branch National Heart, Lung, and Blood Institute National 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