{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:53:34Z","timestamp":1777287214022,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18580125"],"award-info":[{"award-number":["18580125"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Nonalcoholic steatohepatitis (NASH) is a common disease, which is closely associated with inflammation and oxidative stress, and <jats:italic>Lonicera caerulea<\/jats:italic> L. polyphenols (LCP) are reported to possess both antioxidant and anti\u2010inflammatory properties. This study aimed to investigate the protective effects and mechanisms of LCP on NASH in a high\u2010fat diet plus carbon tetrachloride (CCL<jats:sub>4<\/jats:sub>) induced mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Mice were fed with high\u2010fat diet containing LCP (0.5\u20131%) or not, and then administrated with CCL<jats:sub>4<\/jats:sub> to induce NASH. Liver sections were stained by hematoxylin\u2013eosin stain, serum transaminases and lipids were measured by clinical analyzer, insulin was examined by ELISA, cytokines were determined by multiplex technology, and hepatic proteins were detected by Western blotting. LCP improved histopathological features of NASH with lower levels of lipid peroxidation and cytokines including granulocyte colony\u2010stimulating factor, IL\u20103, IL\u20104, macrophage inflammatory protein\u20101\u03b2, IL\u20106, IL\u20105, keratinocyte\u2010derived cytokine, tumor necrosis factor\u2010alpha, IL\u20102, IL\u20101\u03b2, monocytes chemotactic protein\u20101, IL\u201013, IFN\u2010\u03b3, IL\u201010, IL\u201012(p70), IL\u20101\u03b1, eotaxin, granulocyte\u2010macrophage colony\u2010stimulating factor, macrophage inflammatory protein\u20101\u03b1, IL\u201017, and RANTES. Further molecular analysis revealed that LCP increased the expression of nuclear factor (erythroid\u2010derived 2)\u2010like 2 and manganese\u2010dependent superoxide dismutase, but decreased forkhead box protein O1 and heme oxygenase\u20101 in the liver of NASH mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dietary supplementation of LCP ameliorates inflammation and lipid peroxidation by upregulating nuclear factor (erythroid\u2010derived 2)\u2010like 2 and manganese\u2010dependent superoxide dismutase, and downregulating forkhead box protein O1 and heme oxygenase\u20101 in NASH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600858","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T13:38:17Z","timestamp":1481290697000},"source":"Crossref","is-referenced-by-count":38,"title":["Polyphenols from <i>Lonicera caerulea<\/i> L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation"],"prefix":"10.1002","volume":"61","author":[{"given":"Shusong","family":"Wu","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Sciences Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yano","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayami","family":"Hisanaga","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[{"name":"Core Research Program 1515 Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients Hunan Agricultural University  Changsha P. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozue","family":"Sakao","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences Kagoshima University  Kagoshima Japan"},{"name":"Department of Food Science and Biotechnology, Faculty of Agriculture Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010Xing","family":"Hou","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences Kagoshima University  Kagoshima Japan"},{"name":"Core Research Program 1515 Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients Hunan Agricultural University  Changsha P. R. China"},{"name":"Department of Food Science and Biotechnology, Faculty of Agriculture Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23280"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182779d49"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10809"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13568"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030509o"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5021079"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.03.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8026233"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9003994"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4141\/cjps2012-073"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.06.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121240"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.029"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12102"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.22.2685"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2694"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.11.009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22317"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.21-2-236"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2003.10.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.182"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38308"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20559"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.043"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0095"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0232"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201600858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1002%2Fmnfr.201600858","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201600858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:29:50Z","timestamp":1695032990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201600858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/mnfr.201600858"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201600858","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]},"article-number":"1600858"}}