{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:09Z","timestamp":1761709329879,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Agency for Innovation Systems"},{"DOI":"10.13039\/501100009252","name":"Science for Life Laboratory","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The molecular mechanisms underlying the cholesterol\u2010lowering properties of oats are only partly known. To study possible pathways involved, we investigated gene expressions in the liver and small intestine of mice fed oats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method and results<\/jats:title><jats:p>Cholesterol and bile acids were analyzed in plasma and feces from LDL\u2010receptor deficient (LDLr<jats:sup>\u2212\/\u2212<\/jats:sup>) mice fed Western diet with wholegrain oats. A transcriptome analysis of mRNA from liver and jejunum was performed together with quantitative RT\u2010PCR. Oat\u2010fed mice had lower levels of plasma lipids and increased levels of bile acids and cholesterol in feces compared with controls. Two hundred thirty nine genes in jejunum and 25 genes in liver were differentially expressed (FDR corrected <jats:italic>p<\/jats:italic> &lt; 0.05). The most affected biological process in jejunum was lipid biosynthesis and regulation. The apical sodium\u2010dependent bile acid transporter (ASBT, <jats:italic>Slc10a<\/jats:italic>) and the intracellular bile acid binding protein (<jats:italic>Fabp6<\/jats:italic>) were both upregulated, whereas small heterodimer partner\u20101 (<jats:italic>Shp\u20101)<\/jats:italic> and apolipoprotein CII (<jats:italic>Apoc2<\/jats:italic>) were downregulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whole oats attenuated responses typically induced by high\u2010fat diet. Increased expression of genes for intestinal bile acid uptake following oat consumption suggests retention in the gut lumen rather than decreased uptake capacity as cause for the increased bile acid excretion and the concomitant reduction of plasma cholesterol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600874","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T07:23:10Z","timestamp":1487229790000},"source":"Crossref","is-referenced-by-count":9,"title":["Wholegrain oat diet changes the expression of genes associated with intestinal bile acid transport"],"prefix":"10.1002","volume":"61","author":[{"given":"Kristina E.","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Experimental Medical Science Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Chawade","sequence":"additional","affiliation":[{"name":"Department of Plant Breeding Swedish University of Agricultural Sciences  Alnarp Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narda","family":"Thuresson","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rascon","sequence":"additional","affiliation":[{"name":"Food for Health Science Centre Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rickard","family":"\u00d6ste","sequence":"additional","affiliation":[{"name":"Food for Health Science Centre Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olov","family":"Sterner","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Biochemistry Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hellstrand","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"US Food and Drug Administration (FDA) Food labelling: Health claims; Oats and coronary heart disease. 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