{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:18:44Z","timestamp":1789474724934,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Nasturtium plants contain the glucosinolate glucotropaeolin and its corresponding breakdown product benzyl isothiocyanate (BITC), the latter being intensively studied with regard to cancer chemoprevention and anti\u2010inflammatory properties. In addition, recent research has shown that isothiocyanates are able to activate the release of several gut hormones in vitro and in rodent studies. Here, we tested the effects of a dietary nasturtium administration on circulating levels of gut hormones in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Metabolically healthy males (<jats:italic>n<\/jats:italic> = 15) received a single oral dose of 10 g freeze\u2010dried nasturtium leaf material suspended in water or only water (control). Blood samples were taken every hour and serum concentrations of insulin, C\u2010peptide, glucagon\u2010like peptide 1 (GLP\u20101), glucose\u2010dependent insulinotropic peptide (GIP), and peptide (PYY) were analyzed. Oral nasturtium intake resulted in an increased release of PYY over a time period of 6 h whereas circulating levels of other hormones were not changed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the finding that nasturtium consumption enhances secretion of PYY, a key hormone involved in energy regulation, special diets containing nasturtium, or supplementation with nasturtium or BITC might be considered in the treatment of obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600886","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T10:24:22Z","timestamp":1490955862000},"source":"Crossref","is-referenced-by-count":8,"title":["Oral administration of nasturtium affects peptide YY secretion in male subjects"],"prefix":"10.1002","volume":"61","author":[{"given":"Sonja","family":"Schiess","sequence":"first","affiliation":[{"name":"German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke Department of Clinical Nutrition  Arthur\u2010Scheunert\u2010Allee 114\u2010116 D\u201014558 Nuthetal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Platz","sequence":"additional","affiliation":[{"name":"University of Hamburg HAMBURG SCHOOL OF FOOD SCIENCE Institute of Food Chemistry  Grindelallee 117 D\u201020146 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margrit","family":"Kemper","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition Potsdam\u2010Rehbr\u00fccke Department of Clinical Nutrition  Arthur\u2010Scheunert\u2010Allee 114\u2010116 D\u201014558 Nuthetal Germany"},{"name":"Charit\u00e9 University Medicine Department of Endocrinology Diabetes and Nutrition Campus Benjamin Franklin  Hindenburgdamm 30 D\u201012203 Berlin Berlin Germany"},{"name":"German Center for Diabetes Research (DZD)  85764 M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Vegetable and Ornamental Crops Gro\u00dfbeeren\/Erfurt e.V. Department Plant Quality  Theodor\u2010Echtermeyer\u2010Weg 1 D\u201014979 Gro\u00dfbeeren Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Mewis","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Vegetable and Ornamental Crops Gro\u00dfbeeren\/Erfurt e.V. Department Plant Quality  Theodor\u2010Echtermeyer\u2010Weg 1 D\u201014979 Gro\u00dfbeeren Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Rohn","sequence":"additional","affiliation":[{"name":"University of Hamburg HAMBURG SCHOOL OF FOOD SCIENCE Institute of Food Chemistry  Grindelallee 117 D\u201020146 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Bumke\u2010Vogt","sequence":"additional","affiliation":[{"name":"Leibniz Institute of Vegetable and Ornamental Crops Gro\u00dfbeeren\/Erfurt e.V. 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