{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:18:41Z","timestamp":1768702721124,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K15303"],"award-info":[{"award-number":["K15303"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K15302"],"award-info":[{"award-number":["K15302"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The esoteric anti\u2010obesity effects of hyacinth bean (<jats:italic>Dolichos lablab<\/jats:italic> L) have largely remained unexplored. Herein, we investigated the anti\u2010obesity mechanisms of hyacinth bean compared to milk thistle, a natural herb employed for ameliorating obesity\u2010related diseases, using high\u2010fat diet (HFD) fed mice towards unfolding the perplexing mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6J mice were orally administered hyacinth bean (25 mg\/kg\/day) and milk thistle (100 mg\/kg\/day) for 9 weeks along with HFD. Intriguingly, a number of anti\u2010obesity mechanisms indexed through clinical parameters, suppression in weight gains and liver steatosis were found similar to some disparity. Furthermore, the corresponding metabolic implications were studied through MS\u2010based metabolite profiling, and using the Kyoto Encyclopedia of Genes and Genomes for metabolic pathways revealing that hyacinth bean or milk thistle administration effectively attenuates the HFD\u2010induced lipid, glucose, and bile acid metabolism, with former specifically attenuates pyruvate\u2010derived amino acids metabolism. Among them, valine, asparagine, and lysine displayed high correlation with blood clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A lower dose of hyacinth bean resulted in similar anti\u2010obesity effects as milk thistle, as confirmed by both clinical and metabolomics analyses. Equivocally, we conjecture that hyacinth bean could be used as a potent anti\u2010obesity herbal functional food.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600895","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T18:41:02Z","timestamp":1484937662000},"source":"Crossref","is-referenced-by-count":24,"title":["In vivo metabolomic interpretation of the anti\u2010obesity effects of hyacinth bean (<i>Dolichos lablab<\/i> L.) administration in high\u2010fat diet mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Dong Ho","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division \u00a0Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine and Bioscience Daejeon University  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"General guidelines for methodologies on research and evaluation of traditional medicine","author":"World Health Organization","year":"2000","journal-title":"Word Health Organization"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3073"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b766ed"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00405106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01244-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030163b"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.03.053"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.46.812"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00656-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2090653"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-014-0743-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20023107"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-015-0783-x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2015.3623"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.11.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400470"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100892r"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(96)05936-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00707.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.12.821"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100101p"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.305789"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031398"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031777"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0269-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00134.2007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.009"}],"container-title":["Molecular Nutrition &amp; 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