{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:44:07Z","timestamp":1791225847865,"version":"4.1.0"},"reference-count":83,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571874"],"award-info":[{"award-number":["31571874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of the Education Department of Hunan province","award":["13A124"],"award-info":[{"award-number":["13A124"]}]},{"name":"Graduate Innovative Research Project of Hunan province"},{"name":"Central South University of Forestry and Technology","award":["CX2016B23"],"award-info":[{"award-number":["CX2016B23"]}]},{"name":"2011 Collaborative Innovation Center of Hunan province","award":["2013, No. 448"],"award-info":[{"award-number":["2013, No. 448"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Nutr. Food Res."],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1002\/mnfr.201601013","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T07:20:42Z","timestamp":1490858442000},"page":"1601013","source":"Crossref","is-referenced-by-count":89,"title":["Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-\u03baB\/AP-1\/STAT-1 inactivation and PPAR-\u03b3 activation"],"prefix":"10.1002","volume":"61","author":[{"given":"Limin","family":"Shi","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlu","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology; Xiangya Hospital; Central South University; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Nie","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguo","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathology; Medical College; Hunan Normal University; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feijun","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Nutrition; College of Food Science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"10.1002\/mnfr.201601013-BIB0001|mnfr2910-cit-0001","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2004.02.072","article-title":"From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation","volume":"126","author":"Sands","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1002\/mnfr.201601013-BIB0002|mnfr2910-cit-0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.17116\/terarkh201688846-52","article-title":"Long-term infliximab therapy for ulcerative colitis in real clinical practice","volume":"88","author":"Knyazev","year":"2016","journal-title":"Terapevticheskii Arkhiv."},{"key":"10.1002\/mnfr.201601013-BIB0003|mnfr2910-cit-0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394596-9.00009-3","article-title":"Animal models of inflammatory bowel disease","volume":"105","author":"Mizoguchi","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1002\/mnfr.201601013-BIB0004|mnfr2910-cit-0004","doi-asserted-by":"crossref","first-page":"e6073","DOI":"10.1371\/journal.pone.0006073","article-title":"Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis","volume":"4","author":"Yan","year":"2009","journal-title":"PLoS One."},{"key":"10.1002\/mnfr.201601013-BIB0005|mnfr2910-cit-0005","first-page":"1","article-title":"Dextran sodium sulphate colitis mouse model: traps and tricks","volume":"2012","author":"Perse","year":"2012","journal-title":"Biomed. Res. Int."},{"key":"10.1002\/mnfr.201601013-BIB0006|mnfr2910-cit-0006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-8741(99)00154-3","article-title":"Inhibitor of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa","volume":"70","author":"Cho","year":"2000","journal-title":"J. Ethnopharm."},{"key":"10.1002\/mnfr.201601013-BIB0007|mnfr2910-cit-0007","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1388-1981(02)00126-9","article-title":"J.P., Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism","volume":"1581","author":"Yu","year":"2002","journal-title":"Biochim. Biophy. Acta."},{"key":"10.1002\/mnfr.201601013-BIB0008|mnfr2910-cit-0008","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.fct.2013.09.012","article-title":"Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2\/HO-1 pathway and NF-kappaB suppression","volume":"62","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1002\/mnfr.201601013-BIB0009|mnfr2910-cit-0009","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000315915","article-title":"Endotoxins and other sepsis triggers","volume":"167","author":"Opal","year":"2010","journal-title":"Contrib. Nephrol."},{"key":"10.1002\/mnfr.201601013-BIB0010|mnfr2910-cit-0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/1547691X.2015.1029145","article-title":"Modulatory effects of thymol and carvacrol on inflammatory transcription factors in lipopolysaccharide-treated macrophages","volume":"13","author":"Gholijani","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1002\/mnfr.201601013-BIB0011|mnfr2910-cit-0011","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-8981(02)00180-8","article-title":"Initial responses to endotoxins and Gram-negative bacteria","volume":"323","author":"Heumann","year":"2002","journal-title":"Clinica. Chimica. Acta."},{"key":"10.1002\/mnfr.201601013-BIB0012|mnfr2910-cit-0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2005.12.016","article-title":"The analysis of onion and garlic","volume":"1112","author":"Vigrinia","year":"2006","journal-title":"J. Chromatogr. A."},{"key":"10.1002\/mnfr.201601013-BIB0013|mnfr2910-cit-0013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/S15327914NC382_14","article-title":"Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation","volume":"38","author":"Hirsch","year":"2000","journal-title":"Nutr. Cancer"},{"key":"10.1002\/mnfr.201601013-BIB0014|mnfr2910-cit-0014","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/18715206113136660370","article-title":"The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention","volume":"14","author":"Sch\u00e4fer","year":"2014","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0015|mnfr2910-cit-0015","doi-asserted-by":"crossref","first-page":"955S","DOI":"10.1093\/jn\/131.3.955S","article-title":"Intake of garlic and its bioactive components","volume":"131","author":"Amagase","year":"2001","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201601013-BIB0016|mnfr2910-cit-0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0308-8146(92)90024-V","article-title":"Quantitative estimation of garlic oil content in garlic oil based health products","volume":"45","author":"Yan","year":"1992","journal-title":"Food Chem."},{"key":"10.1002\/mnfr.201601013-BIB0017|mnfr2910-cit-0017","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0002-9343(93)90216-C","article-title":"Can garlic reduce levels of serum lipids? A controlled clinical study","volume":"94","author":"Jain","year":"1993","journal-title":"Am. J. Med."},{"key":"10.1002\/mnfr.201601013-BIB0018|mnfr2910-cit-0018","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1254\/fpj.110.supplement_93","article-title":"New pharmacological activities of garlic and its constituents","volume":"110","author":"Sumiyoshi","year":"1997","journal-title":"Nihon. Yakurigaku. Zasshi."},{"key":"10.1002\/mnfr.201601013-BIB0019|mnfr2910-cit-0019","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.fct.2005.07.013","article-title":"Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocininduced diabetes","volume":"44","author":"Liu","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1002\/mnfr.201601013-BIB0020|mnfr2910-cit-0020","first-page":"523","article-title":"Antidiabetic effect of SACS isolated from garlic Allium sativum L","volume":"30","author":"Sheela","year":"1992","journal-title":"Indian J. Exp. Biol."},{"key":"10.1002\/mnfr.201601013-BIB0021|mnfr2910-cit-0021","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/13880209.2010.521163","article-title":"Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats","volume":"49","author":"Nasim","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1002\/mnfr.201601013-BIB0022|mnfr2910-cit-0022","doi-asserted-by":"crossref","first-page":"381815","DOI":"10.1155\/2013\/381815","article-title":"Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes","volume":"2013","author":"Quintero-Fabi\u00e1n","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1002\/mnfr.201601013-BIB0023|mnfr2910-cit-0023","first-page":"238","article-title":"Clinic pathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1002\/mnfr.201601013-BIB0024|mnfr2910-cit-0024","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cyto.2015.11.025","article-title":"Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages","volume":"78","author":"Meshkibaf","year":"2016","journal-title":"Cytokine"},{"key":"10.1002\/mnfr.201601013-BIB0025|mnfr2910-cit-0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1002\/mnfr.201601013-BIB0026|mnfr2910-cit-0026","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3892\/mmr.2013.1635","article-title":"Anti-inflammatory effects of kudingcha methanol extract (Ilex kudingcha C. J. Tseng) in dextran sulfate sodium-induced ulcerative colitis","volume":"8","author":"Song","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1002\/mnfr.201601013-BIB0027|mnfr2910-cit-0027","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jep.2014.12.042","article-title":"Active components alignment of Gegenqinlian decoction protects ulcerative colitis by attenuating inflammatory and oxidative stress","volume":"162","author":"Xu","year":"2015","journal-title":"J. Ethnopharm."},{"key":"10.1002\/mnfr.201601013-BIB0028|mnfr2910-cit-0028","first-page":"1","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"1525","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1002\/mnfr.201601013-BIB0029|mnfr2910-cit-0029","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3382\/ps.0591006","article-title":"Studies on infectious bursal disease in chickens. 2. Scoring microscopic lesions in the bursa of fabricius, thymus, spleen, and kidney in gnotobiotic and battery reared White Leghorns experimentally infected with infectious bursal disease virus","volume":"59","author":"Henry","year":"1980","journal-title":"Poultry Sci."},{"key":"10.1002\/mnfr.201601013-BIB0030|mnfr2910-cit-0030","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/jf051742k","article-title":"Determination of seven organo sulfur compounds in garlic by high performance liquid chromatography","volume":"54","author":"Ichikawa","year":"2006","journal-title":"J. Agri. Food Chem."},{"key":"10.1002\/mnfr.201601013-BIB0031|mnfr2910-cit-0031","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0192-0561(99)00038-7","article-title":"Effect of garlic derivatives (alliin) on peripheral blood cell immune response","volume":"21","author":"Salman","year":"1999","journal-title":"Int. J. Immunopharm."},{"key":"10.1002\/mnfr.201601013-BIB0032|mnfr2910-cit-0032","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/scientificamerican0385-114","article-title":"The chemistry of garlic and onions","volume":"251","author":"Block","year":"1985","journal-title":"Sci Am."},{"key":"10.1002\/mnfr.201601013-BIB0033|mnfr2910-cit-0033","first-page":"1","article-title":"Chemical and shelf life analysis of dry garlic powder: A golden herb","volume":"7","author":"Mariam","year":"2016","journal-title":"Int. J. Agri. Food Sci. Technol."},{"key":"10.1002\/mnfr.201601013-BIB0034|mnfr2910-cit-0034","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejphar.2015.06.003","article-title":"Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K\/Akt\/NF-kappa B pathway","volume":"761","author":"Zhou","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0035|mnfr2910-cit-0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.intimp.2015.01.024","article-title":"Anti-inflammation effect of methyl salicylate 2-O-beta-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS) -treated murine macrophages RAW264.7 cells","volume":"25","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0036|mnfr2910-cit-0036","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2014.09.040","article-title":"Citral inhibits lipopolysaccharide-induced acute lung injury activating PPAR-gamma","volume":"747","author":"Shen","year":"2015","journal-title":"Eur. J Pharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0037|mnfr2910-cit-0037","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.niox.2009.11.009","article-title":"On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease","volume":"22","author":"Saijo","year":"2010","journal-title":"Nitric Oxide."},{"key":"10.1002\/mnfr.201601013-BIB0038|mnfr2910-cit-0038","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"Curr. Drug Targets Inflamm, Allergy"},{"key":"10.1002\/mnfr.201601013-BIB0039|mnfr2910-cit-0039","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0898-6568(99)00018-2","article-title":"Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in raw 264.7 macrophages","volume":"11","author":"Paul","year":"1999","journal-title":"Cell. Signal."},{"key":"10.1002\/mnfr.201601013-BIB0040|mnfr2910-cit-0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signaling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1002\/mnfr.201601013-BIB0041|mnfr2910-cit-0041","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1002\/mnfr.201601013-BIB0042|mnfr2910-cit-0042","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways ac-tivated by stress and inflammation: a 10-yearup date","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1002\/mnfr.201601013-BIB0043|mnfr2910-cit-0043","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"11","key":"10.1002\/mnfr.201601013-BIB0044|mnfr2910-cit-0044","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/mnfr.201200843","article-title":"Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators","volume":"57","author":"You","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"issue":"5","key":"10.1002\/mnfr.201601013-BIB0045|mnfr2910-cit-0045","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/cncr.22888","article-title":"Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells","volume":"110","author":"Das","year":"2007","journal-title":"Cancer"},{"key":"10.1002\/mnfr.201601013-BIB0046|mnfr2910-cit-0046","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuropharm.2009.11.010","article-title":"Targeting p38MAPK pathway for the treatment of Alzheimer's disease","volume":"58","author":"Munoz","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1002\/mnfr.201601013-BIB0047|mnfr2910-cit-0047","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s40256-014-0063-6","article-title":"Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease","volume":"14","author":"Fisk","year":"2014","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1002\/mnfr.201601013-BIB0048|mnfr2910-cit-0048","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1378\/chest.10-1914","article-title":"p38 mitogen-activated protein kinase pathways in asthma and copd","volume":"139","author":"Chung","year":"2011","journal-title":"CHEST J."},{"key":"10.1002\/mnfr.201601013-BIB0049|mnfr2910-cit-0049","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1189\/jlb.1009668","article-title":"Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages","volume":"87","author":"Hsu","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1002\/mnfr.201601013-BIB0050|mnfr2910-cit-0050","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/07853899509002594","article-title":"Nitric oxide-based possibilities for pharmacotherapy","volume":"27","author":"Porsti","year":"1995","journal-title":"Ann. Med."},{"key":"10.1002\/mnfr.201601013-BIB0051|mnfr2910-cit-0051","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0002-9343(00)00480-0","article-title":"Nitric oxide and intestinal inflammation","volume":"109","author":"Kubes","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1002\/mnfr.201601013-BIB0052|mnfr2910-cit-0052","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"8","author":"Gabay","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1002\/mnfr.201601013-BIB0053|mnfr2910-cit-0053","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.4049\/jimmunol.158.11.5267","article-title":"IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: role of octamer binding proteins","volume":"158","author":"Sawada","year":"1997","journal-title":"J. Immunol."},{"key":"10.1002\/mnfr.201601013-BIB0054|mnfr2910-cit-0054","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jep.2012.01.016","article-title":"Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: suppression of NF-kappaB activation and MAPK signaling","volume":"140","author":"Lee","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0055|mnfr2910-cit-0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1021624520740","article-title":"Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage","volume":"243","author":"Cho","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1002\/mnfr.201601013-BIB0056|mnfr2910-cit-0056","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/bph.13040","article-title":"WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in lipopolysaccharide-stimulated RAW264.7 macrophages","volume":"172","author":"Chen","year":"2015","journal-title":"Brit. J. Pharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0057|mnfr2910-cit-0057","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/pr.58.4.5","article-title":"International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors","volume":"58","author":"Michalik","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1002\/mnfr.201601013-BIB0058|mnfr2910-cit-0058","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.intimp.2010.07.007","article-title":"PPARalpha contributes to colonic protection in mice with DSS-induced colitis","volume":"10","author":"Azuma","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1002\/mnfr.201601013-BIB0059|mnfr2910-cit-0059","doi-asserted-by":"crossref","first-page":"10505","DOI":"10.1074\/jbc.274.15.10505","article-title":"Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent transactivating domain","volume":"274","author":"Juge-Aubry","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0060|mnfr2910-cit-0060","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","article-title":"Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1","volume":"274","author":"Delerive","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0061|mnfr2910-cit-0061","doi-asserted-by":"crossref","first-page":"32833","DOI":"10.1074\/jbc.273.49.32833","article-title":"Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging","volume":"273","author":"Poynter","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0062|mnfr2910-cit-0062","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.RES.0000014225.20727.8F","article-title":"PPAR activators as anti-inflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis","volume":"90","author":"Marx","year":"2002","journal-title":"Circ. Res."},{"key":"10.1002\/mnfr.201601013-BIB0063|mnfr2910-cit-0063","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1007\/s10620-006-9644-9","article-title":"PPARbeta\/delta protects against experimental colitis through a ligand-independent mechanism","volume":"52","author":"Hollingshead","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1002\/mnfr.201601013-BIB0064|mnfr2910-cit-0064","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2007.03.113","article-title":"Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice","volume":"133","author":"Lee","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1002\/mnfr.201601013-BIB0065|mnfr2910-cit-0065","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0016-5085(03)00271-3","article-title":"Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis","volume":"124","author":"Dubuquoy","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1002\/mnfr.201601013-BIB0066|mnfr2910-cit-0066","doi-asserted-by":"crossref","first-page":"31771","DOI":"10.1074\/jbc.271.50.31771","article-title":"Insulin-and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma","volume":"271","author":"Zhang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0067|mnfr2910-cit-0067","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1126\/science.274.5295.2100","article-title":"Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma","volume":"274","author":"Hu","year":"1996","journal-title":"Science."},{"key":"10.1002\/mnfr.201601013-BIB0068|mnfr2910-cit-0068","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/24634","article-title":"Interdomain communication regulating ligand binding by PPAR-gamma","volume":"396","author":"Shao","year":"1998","journal-title":"Nature"},{"key":"10.1002\/mnfr.201601013-BIB0069|mnfr2910-cit-0069","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1074\/jbc.272.8.5128","article-title":"Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen- activated protein kinase site","volume":"272","author":"Adams","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0070|mnfr2910-cit-0070","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1128\/MCB.20.13.4699-4707.2000","article-title":"Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene","volume":"20","author":"Li","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1002\/mnfr.201601013-BIB0071|mnfr2910-cit-0071","doi-asserted-by":"crossref","first-page":"36703","DOI":"10.1074\/jbc.M004045200","article-title":"Induction of I kappaB alpha expression as a mechanism contributing to the antinflammatory activities of peroxisome proliferator-activated receptoralpha activators","volume":"275","author":"Delerive","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0072|mnfr2910-cit-0072","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1248\/bpb.b12-00859","article-title":"Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation","volume":"36","author":"Ryu","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1002\/mnfr.201601013-BIB0073|mnfr2910-cit-0073","doi-asserted-by":"crossref","first-page":"27339","DOI":"10.1074\/jbc.274.39.27339","article-title":"The beginning of the end: I kappaB kinase (IKK) and NF-kappaB activation","volume":"274","author":"Karin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0074|mnfr2910-cit-0074","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0016-5085(98)70202-1","article-title":"Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa","volume":"115","author":"Rogler","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1002\/mnfr.201601013-BIB0075|mnfr2910-cit-0075","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2249.2005.02678.x","article-title":"Role of p38MAPK and NF-\u03baB for chemokine release in coculture of human eosinophils and bronchial epithelial cells","volume":"139","author":"Wong","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1002\/mnfr.201601013-BIB0076|mnfr2910-cit-0076","doi-asserted-by":"crossref","first-page":"e00118","DOI":"10.1002\/prp2.118","article-title":"Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses","volume":"3","author":"Zhang","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1002\/mnfr.201601013-BIB0077|mnfr2910-cit-0077","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3892\/mmr.2016.5444","article-title":"Effects of AP-1 and NF-\u03baB inhibitors on colonic endocrine cells in rats with TNBS-induced colitis","volume":"14","author":"El-Salhy","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1002\/mnfr.201601013-BIB0078|mnfr2910-cit-0078","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/labinvest.2008.38","article-title":"Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis","volume":"88","author":"Moriyama","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1002\/mnfr.201601013-BIB0079|mnfr2910-cit-0079","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cbi.2015.04.015","article-title":"\u03b1-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock","volume":"235","author":"Lee","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1002\/mnfr.201601013-BIB0080|mnfr2910-cit-0080","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","article-title":"Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1","volume":"274","author":"Delerive","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0081|mnfr2910-cit-0081","doi-asserted-by":"crossref","first-page":"33471","DOI":"10.1074\/jbc.M102839200","article-title":"Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box\/enhancer-binding protein beta","volume":"276","author":"Gervois","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0082|mnfr2910-cit-0082","doi-asserted-by":"crossref","first-page":"32681","DOI":"10.1074\/jbc.M002577200","article-title":"Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-\u03baB","volume":"275","author":"Chung","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201601013-BIB0083|mnfr2910-cit-0083","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1172\/JCI118991","article-title":"Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia","volume":"98","author":"Law","year":"1996","journal-title":"J. Clin. Invest."}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201601013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mnfr.201601013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:40:02Z","timestamp":1692744002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201601013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1002\/mnfr.201601013","archive":["Portico"],"relation":{},"ISSN":["1613-4125"],"issn-type":[{"value":"1613-4125","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}