{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:20:12Z","timestamp":1787977212153,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["(2013\u2010A\u201010)"],"award-info":[{"award-number":["(2013\u2010A\u201010)"]}],"id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>\u03b2\u2010Cryptoxanthin and astaxanthin are antioxidant carotenoid pigments that inhibit lipid peroxidation as potently as vitamin E. We hypothesized that acute treatment with \u03b2\u2010cryptoxanthin and astaxanthin causes similar reductions in the sizes of cardiac infarcts caused by ischemia\u2010reperfusion (I\/R) injury by attenuating oxidative stress and cardiac mitochondrial dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>C57BL\/6 mice (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) were randomized to receive vehicle, \u03b2\u2010cryptoxanthin, astaxanthin, or vitamin E at 50 mg\/kg by gavage feeding prior to I\/R injury. Cardiac I\/R was induced by left anterior descending coronary artery ligation followed by reperfusion. All treatments significantly reduced infarct sizes by 36\u201357%, attenuated apoptosis and also attenuated cardiac mitochondrial dysfunction in the treated groups compared to the control group. Although astaxanthin and vitamin E exhibited similar efficacy with respect to cardioprotection, \u03b2\u2010cryptoxanthin exhibited greater efficacy than its counterparts, as it reduced infarct sizes by 60%. \u03b2\u2010Cryptoxanthin was more effective than astaxanthin and vitamin E because it reduced cardiac mitochondrial swelling, mitochondrial depolarization, the Bax\/Bcl\u20102 ratio, and plasma and cardiac thiobarbituric acid reactive substances levels more significantly than its counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute \u03b2\u2010cryptoxanthin treatment exhibits greater cardioprotective efficacy against I\/R injury than astaxanthin and vitamin E by reducing infarct sizes and attenuating apoptosis, oxidative stress, and mitochondrial dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201601077","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:18:58Z","timestamp":1495574338000},"source":"Crossref","is-referenced-by-count":38,"title":["\u03b2\u2010Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia\u2010reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Wanpitak","family":"Pongkan","sequence":"first","affiliation":[{"name":"Department of Cell Metabolism and Nutrition Brain\/Liver Interface Medicine Research Center Kanazawa University  Kanazawa Japan"},{"name":"Cardiac Electrophysiology Research and Training Center Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Unit Department of Physiology Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Center of Excellence in Cardiac Electrophysiology Research Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of System Biology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhua","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Cell Metabolism and Nutrition Brain\/Liver Interface Medicine Research Center Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cell Metabolism and Nutrition Brain\/Liver Interface Medicine Research Center Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Cell 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