{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:21:31Z","timestamp":1771467691862,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472053"],"award-info":[{"award-number":["31472053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572345"],"award-info":[{"award-number":["31572345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Resveratrol is a naturally occurring polyphenolic compound with known cardioprotective, anti\u2010inflammatory, and antioxidant properties. Lipoprotein\u2010associated phospholipase A<jats:sub>2<\/jats:sub> (Lp\u2010PLA<jats:sub>2<\/jats:sub>) is associated with the risk of cardiovascular disease. Here, we investigated the effects of resveratrol on Lp\u2010PLA<jats:sub>2<\/jats:sub> expression in vitro and in vivo and explored the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Human monocytic cells (THP\u20101) were induced to differentiate into macrophages for an in vitro experimental model. Resveratrol suppressed Lp\u2010PLA<jats:sub>2<\/jats:sub> expression and reduced inflammation; lipopolysaccharide (LPS, 1 \u03bcg\/mL), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1, 10 ng\/mL) and reactive oxygen species (ROS) were employed to stimulate an increase in Lp\u2010PLA<jats:sub>2<\/jats:sub> expression and ROS levels, and the stimulation was inhibited by resveratrol (50 \u03bcM) and other antioxidants. The inhibition of resveratrol was inversed partially by sirtuin 1 (SIRT1) inhibitors (Nicotinamide, 1\u201310 mM) (<jats:italic>p&lt;<\/jats:italic>0.05). Next, a chronic inflammation mouse model induced by a HFD (high fat diet) supplemented with resveratrol 100 mg\/kg\/day orally for 12 weeks, resulted in resveratrol\u2010induced decreases in the Lp\u2010PLA<jats:sub>2<\/jats:sub> levels in the plasma and liver and increases in the superoxide dismutase 2 (SOD2) expression in the liver (<jats:italic>p&lt;<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our results, the protective effects of resveratrol on cardiovascular events may be related to its ability to suppress Lp\u2010PLA<jats:sub>2<\/jats:sub> expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201601112","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T08:22:45Z","timestamp":1497342165000},"source":"Crossref","is-referenced-by-count":20,"title":["Resveratrol suppresses lipoprotein\u2010associated phospholipase A<sub>2<\/sub> expression by reducing oxidative stress in macrophages 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