{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:44:26Z","timestamp":1791315866043,"version":"4.3.1"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French governmental ANR","award":["ANR-11-IDEX-0003-02"],"award-info":[{"award-number":["ANR-11-IDEX-0003-02"]}]},{"name":"Agence Nationale de le Recherche","award":["ANR-10-EQPX-03"],"award-info":[{"award-number":["ANR-10-EQPX-03"]}]},{"name":"Agence Nationale de le Recherche","award":["ANR10-INBS-09-08"],"award-info":[{"award-number":["ANR10-INBS-09-08"]}]},{"name":"Canceropole Ile-de-France"},{"name":"Idex ALias","award":["RPAIB 13000682"],"award-info":[{"award-number":["RPAIB 13000682"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Rats received for 3 weeks two diets of identical composition but based on lipid\u2010protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion. LFE diet led to higher abundance, when compared to the GCE, of Lactobacillaceae (<jats:italic>Lactobacillus reuteri)<\/jats:italic> in the ileum, higher \u03b2\u2010diversity of the caecum mucus\u2010associated bacteria. In contrast, the LFE diet led to a decrease in <jats:italic>Akkermansia municiphila<\/jats:italic> in the caecum. This coincided with heavier caecum content and higher amount of isovalerate in the LFE group. LFE diet induced an increased expression of (i) amino acid transporters in the ileum (ii) glucagon in the caecum, together with an elevated level of GLP\u20101 in portal plasma. However, these intestinal effects were not associated with modification of food intake or body weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, the structure of protein emulsion in food affects the expression of amino acid transporters and gut peptides concomitantly with modification of the gut microbiota composition and activity. Our data suggest that these effects of the emulsion structure are the result of a modification of protein digestion properties.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700078","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T08:23:35Z","timestamp":1495009415000},"source":"Crossref","is-referenced-by-count":18,"title":["Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats"],"prefix":"10.1002","volume":"61","author":[{"given":"Martin","family":"Beaumont","sequence":"first","affiliation":[{"name":"UMR PNCA AgroParisTech INRA Universit\u00e9 Paris\u2010Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphn\u00e9","family":"Jaoui","sequence":"additional","affiliation":[{"name":"MICALIS Institute INRA AgroParisTech Universit\u00e9 Paris\u2010Saclay  78350 Jouy\u2010en\u2010Josas 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