{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:58:53Z","timestamp":1790114333827,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["710002\u201007\u20107sb310"],"award-info":[{"award-number":["710002\u201007\u20107sb310"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015R1A2A1A10053567"],"award-info":[{"award-number":["2015R1A2A1A10053567"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti\u2010obesity effect of gingerenone A (GA) in diet\u2010induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3\u2010L1 cells among ginger components tested at a single concentration (40\u00a0\u03bcM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP\u2010activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro\u2010inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700139","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T04:22:42Z","timestamp":1496031762000},"source":"Crossref","is-referenced-by-count":122,"title":["Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high\u2010fat diet\u2010fed mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Sujin","family":"Suk","sequence":"first","affiliation":[{"name":"Major in Biomodulation, Department of Agricultural Biotechnology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyoo Taik","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Hallym University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Lee","sequence":"additional","affiliation":[{"name":"Major in Biomodulation, Department of Agricultural Biotechnology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jung","family":"Jang","sequence":"additional","affiliation":[{"name":"Major in Biomodulation, Department of Agricultural Biotechnology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee","family":"Yang","sequence":"additional","affiliation":[{"name":"Major in Biomodulation, Department of Agricultural Biotechnology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Agriculture and Life Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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