{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:36:34Z","timestamp":1780508194271,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M601997"],"award-info":[{"award-number":["2016M601997"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>(\u2010)\u2010Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea, and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A hyperlipidemic rat model was induced by high\u2010fat, high\u2010cholesterol diet. EC was then administrated to the animals by gavage at doses of 10, 20, 40 mg\/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control. The results showed that EC significantly reduced total cholesterol, LDL cholesterol and triglyceride, alleviated liver fat accumulation, while increased HDL cholesterol, in hyperlipidemic rats. EC also reduced lipid peroxidation, inhibited the pro\u2010inflammatory cytokines, and lowered serum AST and ALT. The potential molecular mechanisms of EC underlying these effects were proposed to be associated to regulating Insig\u20101\u2010SREBP\u2010SCAP pathway, and other lipid metabolic related genes including LXR\u2010\u03b1, FAS, and SIRT1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EC effectively improved blood lipid profile and protected liver from accumulating excessive fat in hyperlipidemic rats. The results shed a light on the potential role of EC as a promising natural product in preventing hyperlipidemia and nonalcoholic fatty liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700303","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T04:22:40Z","timestamp":1500697360000},"source":"Crossref","is-referenced-by-count":68,"title":["(\u2010)\u2010Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high\u2010fat diet"],"prefix":"10.1002","volume":"61","author":[{"given":"Hui","family":"Cheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Xin'an Medicine Ministry of Education Anhui Province Key Laboratory of R&amp;D of Chinese Medicine Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Henan University of Chinese Medicine  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Su","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine Ministry of Education Anhui Province Key Laboratory of R&amp;D of Chinese Medicine Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine Ministry of Education Anhui Province Key Laboratory of R&amp;D of Chinese Medicine Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Wu","sequence":"additional","affiliation":[{"name":"Nutrient Data Laboratory USDA ARS Beltsville Human Nutrition Research Center  Beltsville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine Ministry of Education Anhui Province Key Laboratory of R&amp;D of Chinese Medicine Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328010a05b"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012477"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2012.11.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199806000-00013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.10.001"},{"key":"e_1_2_7_7_1","first-page":"551","article-title":"Pharmacologic treatment of hyperlipidemia","volume":"84","author":"Last A. R.","year":"2011","journal-title":"Am. Fam. Physician."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793176464"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2011.629354"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071811-150642"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-015-0419-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.05.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510168103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5665"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1185"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf205370q"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000212Y.0000000020"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.023"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.145482"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.64"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.023457"},{"key":"e_1_2_7_22_1","first-page":"CD009934","article-title":"Green and black tea for the primary prevention of cardiovascular disease","volume":"6","author":"Hartley L.","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2011.08.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.01.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i34.12082"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i6.846"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2014.952399"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.09.007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.158"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-015-0469-z"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119784"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v59.29018"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.01909"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.15197\/sabad.1.11.47"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008044"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12532"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200793"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00227.2012"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798764780"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.211888"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.199687"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/181260"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.08.044"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.12.027"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283358a58"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.148544"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215593"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs02866"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.016"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.850400"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881749"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.003"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.122978"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.053"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201700303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201700303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:26:36Z","timestamp":1695032796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201700303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/mnfr.201700303"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201700303","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]},"article-number":"1700303"}}