{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:42:56Z","timestamp":1783647776260,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009042","name":"Universidad de Sevilla","doi-asserted-by":"publisher","award":["VPPI\u2010US for the Ruth Hornedo\u2010Ortega"],"award-info":[{"award-number":["VPPI\u2010US for the Ruth Hornedo\u2010Ortega"]}],"id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009042","name":"Universidad de Sevilla","doi-asserted-by":"publisher","award":["Ana B. Cer"],"award-info":[{"award-number":["Ana B. 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The inhibition of amyloid\u2010\u03b2 peptide assembly, the destabilization of amyloid\u2010\u03b2 peptide aggregates, and the decrease of its cytotoxicity for the prevention of neuronal death are considered neuroprotective effects. In this work, the protective effects against amyloid\u2010\u03b2 peptide aggregation and cytotoxicity of eight indolic compounds are evaluated: tryptophan, tryptamine, serotonin, tryptophol, <jats:italic>N\u2010<\/jats:italic>acetylserotonin, 3\u2010indoleacetic acid, tryptophan ethyl ester, and melatonin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Thioflavin T spectroscopic assay, transmission electron microscopy, western blotting, circular dichroism, NMR, cell viability (thiazolyl blue tetrazolium bromide assay), quantitative PCR, and heme oxygenase activity are used. Serotonin is the most effective compound for inhibiting amyloid\u2010\u03b2 peptide aggregation. Almost all the indolic compounds tested prevent amyloid\u2010\u03b2 peptide\u2010induced and increase cell viability, being between 9 and 25%. Melatonin and serotonin are the most active. Moreover, serotonin increased the expression of SIRT\u20101 and 2, heat shock protein 70, and heme oxygenase activity, this being a possible mechanism underlying the observed neuroprotective effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Melatonin and other related indolic compounds, mainly serotonin, show an inhibitory and destabilizing effect on amyloid\u2010\u03b2 peptide fibril formation and they possess neuroprotective properties related to the vitagenes system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700383","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T04:22:51Z","timestamp":1510546971000},"source":"Crossref","is-referenced-by-count":51,"title":["In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid\u2010\u03b2 Kinetics and Neuroprotection"],"prefix":"10.1002","volume":"62","author":[{"given":"Ruth","family":"Hornedo\u2010Ortega","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Toxicolog\u00eda y Medicina Legal, \u00c1rea de Nutrici\u00f3n y Bromatolog\u00eda Facultad de Farmacia Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Da Costa","sequence":"additional","affiliation":[{"name":"ISVV Unit\u00e9 de Recherche Oenologie Universit\u00e9 de Bordeaux  Villenave d'Ornon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Cerezo","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Toxicolog\u00eda y Medicina Legal, \u00c1rea de Nutrici\u00f3n y Bromatolog\u00eda Facultad de Farmacia Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Toxicolog\u00eda y Medicina Legal, \u00c1rea de Nutrici\u00f3n y Bromatolog\u00eda Facultad de Farmacia Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Richard","sequence":"additional","affiliation":[{"name":"ISVV Unit\u00e9 de Recherche Oenologie Universit\u00e9 de Bordeaux  Villenave d'Ornon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Garcia\u2010Parrilla","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bromatolog\u00eda, Toxicolog\u00eda y Medicina Legal, \u00c1rea de Nutrici\u00f3n y Bromatolog\u00eda Facultad de Farmacia Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132814"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001867"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802607779318262"},{"key":"e_1_2_8_6_1","first-page":"1","volume":"1565","author":"Hornedo\u2010Ortega R.","year":"2016","journal-title":"Front. 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