{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:23:16Z","timestamp":1768720996009,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010739","name":"University of Camerino","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010739","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The aim of our work was to produce a hydroalcoholic extract of lentils and to examine (a) the hypocholesterolemic action in an animal model, by studying the plasma cholesterol level and the concentration of bile acids in the feces; (b) the potential prebiotic effect, by conducting an in vitro culture fermentation experiment and assessing the level of SCFAs in the feces of rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Lentil extract (LE) was obtained by extracting lentils with a solution of H<jats:sub>2<\/jats:sub>0\/EtOH (70\/30 v\/v) for 3 h, and the content of main nutrients was determined. After 71\u00a0days of diet\u2010induced hypercholesterolemia in rats, LE reduced the cholesterol level of rats of 16.8% (<jats:italic>p<\/jats:italic> &lt; 0.05) and increased the level of bile acids in the feces of rats (<jats:italic>p<\/jats:italic> &lt; 0.01). LE revealed the same prebiotic activity of inulin and good bifidogenic activity, inasmuch as it enhanced the growth of <jats:italic>Bifidobacterium<\/jats:italic> spp. by 3 log (<jats:italic>p<\/jats:italic> &lt; 0.05). The concentration of SCFAs in the feces of rats fed with LE increased during the time of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This new hydroalcoholic extract obtained from lentils was shown to possess hypocholesterolemic and prebiotic properties, and could have interesting applications in the field of nutraceuticals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700403","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:45:25Z","timestamp":1500626725000},"source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of the hypocholesterolemic effect and prebiotic activity of a lentil (<i>Lens culinaris<\/i> Medik) extract"],"prefix":"10.1002","volume":"61","author":[{"given":"Maria Vittoria","family":"Micioni Di Bonaventura","sequence":"first","affiliation":[{"name":"Pharmacology Unit School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Cecchini","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"},{"name":"Synbiotec Srl Spin\u2010Off of University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Vila\u2010Donat","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cifani","sequence":"additional","affiliation":[{"name":"Pharmacology Unit School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Magdalena","family":"Coman","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"},{"name":"Synbiotec Srl Spin\u2010Off of University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cresci","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"},{"name":"Synbiotec Srl Spin\u2010Off of University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Chemistry Division School of Science and Technology University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ricciutelli","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Silvi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine University of Camerino  Camerino Italy"},{"name":"Synbiotec Srl Spin\u2010Off of University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sauro","family":"Vittori","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Sagratini","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2003.07.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2009.09.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602435"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.5.865"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.6.9609168"},{"key":"e_1_2_8_7_1","first-page":"79","article-title":"Could saponins be a useful treatment for hypocholesterolaemia?","volume":"44","author":"Oakenfull D.","year":"1990","journal-title":"Eur. 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