{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:40:39Z","timestamp":1790246439132,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010Carn0016"],"award-info":[{"award-number":["ANR\u201015\u2010Carn0016"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010CE21\u20100003"],"award-info":[{"award-number":["ANR\u201016\u2010CE21\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium species. In mammals, this toxin causes widespread organ\u2010specific damage; it promotes hepatotoxicity, is immunotoxic, alters intestinal functions etc. Despite its inhibitory effect on de novo ceramide synthesis, its molecular mechanism of action and toxicity is not totally elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>To explore the mechanism of FB1 toxicity, we analyzed the transcriptome and the kinome of two organs targeted by FB1: the liver and the jejunum. Pigs were fed for 4 weeks a control diet or a FB1\u2010contaminated diet (10 mg\/kg). As expected, FB1\u2010exposed pigs gained less weight and displayed a higher sphinganine\/sphingosine ratio. Comparison of the transcriptomes and the kinomes of treated versus control pigs showed striking differences. Among the disrupted pathways in liver and jejunum, we highlight Protein Kinase B (AKT) \/ Phosphatase and tensin homolog (PTEN) at the intersection of the FB1\u2010modulated pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most of the effects of FB1 are mediated by the regulation of ceramide level, which influences protein phosphatase 2 (PP2A) and the phosphoinositide 3\u2010kinase (PI3K)\/AKT signaling pathway. This pathway might be a new target to counteract toxic effect of Fumonisin B1, which is one of the most spread food contaminant in the world.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700433","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T01:52:45Z","timestamp":1504662765000},"source":"Crossref","is-referenced-by-count":33,"title":["Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine"],"prefix":"10.1002","volume":"61","author":[{"given":"Marion","family":"R\u00e9gnier","sequence":"first","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Gourbeyre","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pinton","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Napper","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Organization \u2010 International Vaccine Center University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Department of Biochemistry University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Laffite","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Cossalter","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Denis","family":"Bailly","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Lippi","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bertrand\u2010Michel","sequence":"additional","affiliation":[{"name":"MetaToul\u2010Lipidomic Facility\u2010MetaboHUB INSERM UMR1048 Institute of Cardiovascular and Metabolic Diseases Universit\u00e9 Paul Sabatier\u2010Toulouse III  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula F.R.L.","family":"Bracarense","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina Laboratory of Animal Pathology Campus Universit\u00e1rio  Londrina Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Guillou","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Loiseau","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle P.","family":"Oswald","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology) Universit\u00e9 de Toulouse, INRA, ENVT, INP\u2010Purpan, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"318","volume-title":"Fungi: Applications and Management Strategies","author":"Cano P. 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