{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:11:37Z","timestamp":1790820697547,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004757","name":"General Mills","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Independently, prebiotics and dietary protein have been shown to improve weight loss and\/or alter appetite. Our objective was to determine the effect of combined prebiotic and whey protein on appetite, body composition and gut microbiota in adults with overweight\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In a 12 week, placebo\u2010controlled, double\u2010blind study, 125 adults with overweight\/obesity were randomly assigned to receive isocaloric snack bars of: (1) Control; (2) Inulin\u2010type fructans (ITF); (3) Whey protein; (4) ITF\u00a0+\u00a0Whey protein. Appetite, body composition and gut microbiota composition\/genetic potential were assessed. Compared to Control, body fat was significantly reduced in the Whey protein group at 12\u00a0wks. Hunger, desire to eat and prospective food consumption were all lower with ITF, Whey protein and ITF\u00a0+\u00a0Whey protein compared to Control at 12 wks. Microbial community structure differed from 0 to 12 wks in the ITF and ITF +Whey Protein groups (i.e. increased <jats:italic>Bifidobacterium<\/jats:italic>) but not Whey Protein or Control. Changes in microbial genetic potential were seen between Control and ITF\u2010containing treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding ITF, whey protein or both to snack bars improved several aspects of appetite control. Changes in gut microbiota may explain in part the effects of ITF but likely not whey protein.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700484","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:21:01Z","timestamp":1500625261000},"source":"Crossref","is-referenced-by-count":129,"title":["Inulin\u2010type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight\/obesity: A randomized controlled trial"],"prefix":"10.1002","volume":"61","author":[{"given":"Raylene A.","family":"Reimer","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Canada"},{"name":"Department of Biochemistry and Molecular Biology Cumming School of Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly J.","family":"Willis","sequence":"additional","affiliation":[{"name":"General Mills Bell Institute of Health and Nutrition  Golden Valley MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine M.","family":"Tunnicliffe","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heekuk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Centre of Excellence for Gastrointestinal Inflammation and Immunity Research University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Centre of Excellence for Gastrointestinal Inflammation and Immunity Research University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Soto\u2010Vaca","sequence":"additional","affiliation":[{"name":"General Mills Bell Institute of Health and Nutrition  Golden Valley MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.05.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00280.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1616\/1476-2137.15880"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28095"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.09.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.06.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/4441022a"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504978102"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512002589"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.044321"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.12.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.05.011"},{"key":"e_1_2_9_14_1","first-page":"pii","article-title":"Appetite and food intake after consumption of sausages with 10% fat and added wheat or rye bran","author":"Vuholm S.","year":"2013","journal-title":"Appetite"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27465"},{"key":"e_1_2_9_16_1","first-page":"S36","article-title":"Godin leisure\u2010time exercise questionnaire","author":"Godin G.","year":"1997","journal-title":"Med. 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