{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:56:54Z","timestamp":1769846214340,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8F0251"],"award-info":[{"award-number":["CMRPG8F0251"]}]},{"name":"Chang Gung Memorial Hospital, Kaohsiung, Taiwan","award":["CMRPG8F1031"],"award-info":[{"award-number":["CMRPG8F1031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>We investigate whether early supplementation of precursors of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010cysteine can prevent hypertension and kidney damage in spontaneously hypertensive rats (SHR) treated with high\u2010salt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We examine 12\u2010week\u2010old male SHRs from four groups: SHR, high salt SHR (SHRs received 1% NaCl in drinking water for 8 weeks), high salt SHR+<jats:sc>d<\/jats:sc> (SHRs received high salt and <jats:sc>d\u2010<\/jats:sc>cysteine), and high salt SHR+<jats:sc>l<\/jats:sc> (SHRs received high salt and <jats:sc>l<\/jats:sc>\u2010cysteine). <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010cysteine was supplemented at 8 mmol kg<jats:sup>\u22121<\/jats:sup> body weight\/day between 4 and 6 weeks of ages. High salt intake exacerbate hypertension and kidney damage in SHRs, which is prevented by <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010cysteine supplementation. <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010Cysteine supplementation reduce the degree of high salt\u2010induced oxidative stress damage. Renal 3\u2010mercaptopyruvate sulphurtransferase (3MST) protein levels and activity are reduced by <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010cysteine supplementation. Additionally, <jats:sc>d\u2010<\/jats:sc> or <jats:sc>l<\/jats:sc>\u2010Cysteine supplementation reduce renal angiotensin I and angiotensin II concentrations, decrease mRNA expression of <jats:italic>Ren<\/jats:italic>, and increase protein levels of type 2 angiotensin II receptor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early supplementation of <jats:sc>d<\/jats:sc>\u2010 or <jats:sc>l<\/jats:sc>\u2010cysteine before hypertension becomes evident and may protect against hypertension and kidney damage in adult SHRs exposed to high salt consumption via regulation of oxidative stress, renin\u2010angiotensin system, and H<jats:sub>2<\/jats:sub>S\u2010generating pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700596","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T14:52:39Z","timestamp":1507215159000},"source":"Crossref","is-referenced-by-count":39,"title":["Early Supplementation of <scp>d<\/scp>\u2010Cysteine or <scp>l<\/scp>\u2010Cysteine Prevents Hypertension and Kidney Damage in Spontaneously Hypertensive Rats Exposed to High\u2010Salt Intake"],"prefix":"10.1002","volume":"62","author":[{"given":"Chien\u2010Ning","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"School of Pharmacy Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ju","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Chen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Lin","family":"Tain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1278316"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0915-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f29876"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00250.2005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6596"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.01.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.05.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00314.2004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150711773"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.08.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2003.11.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.643365"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2015.12.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040357"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.06.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00299"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000175519.34933.a5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.33549\/physiolres.933438","volume":"65","author":"Cacanyiova S.","year":"2016","journal-title":"Physiol. 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