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On the other hand, quercetin (QCT) is a dietary flavonoid with known antitumor, anti\u2010inflammatory, and antidiabetic effects. Additionally, QCT increases autophagy. To study the hypothetical synergistic effect of both compounds, we test the combined effect of QCT and RSV on the autophagy process in HepG2 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Autophagy is studied by western blotting, real\u2010time RT\u2010PCR, and cellular staining. Our results clearly indicate a bifunctional molecular effect of RSV. Both polyphenols are individually able to promote autophagy. Strikingly, when RSV is combined with QCT, it promotes a potent reduction of QCT\u2010induced autophagy and influences proapoptotic signaling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RSV acts differentially on the autophagic process depending on the cellular energetic state. We further characterize the molecular mechanisms related to this effect, and we observe that AMP\u2010activated protein kinase (AMPK) phosphorylation, heme oxygenase 1 (HO\u20101) downregulation, lysosomal membrane permeabilization (LMP), and Zinc (Zn<jats:sup>2+<\/jats:sup>) dynamics could be important modulators of such RSV\u2010related effects and could globally represent a promising strategy to sensitize cancer cells to QCT treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700610","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T06:52:39Z","timestamp":1516085559000},"source":"Crossref","is-referenced-by-count":31,"title":["Resveratrol Potently Counteracts Quercetin Starvation\u2010Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis"],"prefix":"10.1002","volume":"62","author":[{"given":"Sarah","family":"Tomas\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Cheminformatic and Nutrition Research Group 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