{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:20:58Z","timestamp":1792448458389,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA120915"],"award-info":[{"award-number":["CA120915"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA211437"],"award-info":[{"award-number":["CA211437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA72720"],"award-info":[{"award-number":["CA72720"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES005022"],"award-info":[{"award-number":["ES005022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>The tea polyphenol (\u2010)\u2010epigallocatechin\u20103\u2010gallate (EGCG) has been shown to ameliorate metabolic abnormalities and fatty liver. The present study investigates the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male C57BL\/6J mice are fed a low\u2010fat diet, a high\u2010fat western\u2010style diet, or a high\u2010fat western\u2010style diet containing 0.32% EGCG. The effects of the treatments on biochemical parameters, gene expression, and lipidomics are analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EGCG treatment significantly reduces body weight gain, mesenteric fat mass, fasting blood glucose, insulin resistance, serum cholesterol, and severity of fatty liver after treatment for 17 weeks, but most of these effects were less apparent at week 33. At week 17, EGCG treatment significantly elevates the mRNA levels of cholesterol 7\u03b1\u2010hydroxylase, HMG\u2010CoA reductase, low\u2010density lipoprotein receptor, and scavenger receptor B1, and partially normalizes the high\u2010fat diet induced lipidomic profile. The intestinal bile acid content is significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol, and total lipids are increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreases the absorption of lipids. These actions contribute to the alleviation of metabolic abnormalities and fatty liver disease caused by the high\u2010fat diet.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201700696","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T06:52:43Z","timestamp":1514271163000},"source":"Crossref","is-referenced-by-count":133,"title":["Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice"],"prefix":"10.1002","volume":"62","author":[{"given":"Jinbao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"},{"name":"International Joint Research Laboratory of Tea Chemistry and Health Effects State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University  Hefei P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"},{"name":"Visiting student from College of Food Science and Technology Nanjing Agricultural University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Reuhl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Lewis\u2010Sigler Institute for Integrative Genomics Princeton University  Princeton NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers the State University of New Jersey  Piscataway NJ USA"},{"name":"International Joint Research Laboratory of Tea Chemistry and Health Effects State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University  Hefei P. 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