{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:16:47Z","timestamp":1789885007883,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["P50 AT008661\u201001"],"award-info":[{"award-number":["P50 AT008661\u201001"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress\u2010induced depression\/anxiety phenotypes are coincidental with increased inflammation in both brain and blood. The authors recently showed that a novel treatment with a select bioactive polyphenol preparation promotes resilience to stress\u2010mediated depression\/anxiety phenotypes mice. Moreover, selective bioactive phenolic compounds within the polyphenol preparation are identified that are effective in mitigating the behavioral effects of bone marrow transplantation from stressed mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Here, an animal model of adult stress and bone marrow transplantation is used to identify an epigenetic signature of repeated social defeat stress (RSDS) that is passed through bone marrow hematopoietic progenitor cells to na\u00efve mice, revealing the maintenance of epigenetic memory following stress both centrally and peripherally. Further, polyphenols are administered to na\u00efve and stress\u2010susceptible mice, demonstrating that polyphenol treatment in mice from both susceptible and na\u00efve donors alters global DNA methylation in the central nervous system and periphery and likewise has an effect on human blood cells after immune challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings highlight the enduring molecular memory of stress and the possible mechanism by which select bioactive polyphenols may promote resiliency to stress. Polyphenols may be an efficacious alternative to traditional pharmacological treatments in psychiatry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700722","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T06:24:00Z","timestamp":1519367040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Polyphenolic Compounds Alter Stress\u2010Induced Patterns of Global DNA Methylation in Brain and Blood"],"prefix":"10.1002","volume":"62","author":[{"given":"Jennifer","family":"Blaze","sequence":"first","affiliation":[{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York NY 10029"},{"name":"Research and Development Service James J. Peters Veterans Affairs Medical Center  Bronx NY 10468"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lap","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mendelev","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York NY 10029"},{"name":"Research and Development Service James J. Peters Veterans Affairs Medical Center  Bronx NY 10468"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Maria","family":"Pasinetti","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York NY 10029"},{"name":"Research and Development Service James J. Peters Veterans Affairs Medical Center  Bronx NY 10468"},{"name":"James J. Peters Veterans Affairs Medical Center Geriatric Research Education and Clinical Center  Bronx NY 10468"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00990-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22084"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.11.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3722"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120972"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.09.018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.361"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415191111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153252"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.04.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2014.16.3\/rbagot","volume":"16","author":"Bagot R. 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