{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:05Z","timestamp":1790740505649,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104\u20102313\u2010B\u2010002\u2010043\u2010MY3"],"award-info":[{"award-number":["MOST 104\u20102313\u2010B\u2010002\u2010043\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a common disease that is concomitant with obesity, resulting in increased mortality. To date, the efficiency of NAFLD treatment still needs to be improved. Therefore, we aimed to evaluate the effect of <jats:italic>Lactobacillus mali<\/jats:italic> APS1, which was isolated from sugary kefir, on hepatic steatosis in rats fed a high\u2010fat diet (HFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sprague Dawley rats were fed a control diet, a HFD with saline, and a HFD with APS1 intervention by gavage daily for 12 weeks. The results showed that APS1 significantly reduced body weight and body weight gain in HFD\u2010fed rats. APS1 reduced hepatic lipid accumulation by regulating SIRT\u20101\/PGC\u20101\u03b1\/SREBP\u20101 expression. Moreover, APS1 increased hepatic antioxidant activity by modulating Nrf\u20102\/HO\u20101 expression. Notably, APS1 manipulated the gut microbiota, resulting in increasing proportions of the phylum Bacteroidetes\/Firmicutes and reducing the abundance of specific NAFLD\u2010associated bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggested that APS1 ameliorated hepatic steatosis by modulating lipid metabolism and antioxidant activity via manipulating specific NAFLD\u2010associated gut microbiota in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700903","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T02:56:42Z","timestamp":1520305002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Sugary Kefir Strain <i>Lactobacillus mali<\/i> APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT\u20101\/Nrf\u20102 and Gut Microbiota in Rats"],"prefix":"10.1002","volume":"62","author":[{"given":"Yung\u2010Tsung","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Biotechnology National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Livestock Research Institute Council of Agriculture  Executive Yuan Tainan Taiwan"},{"name":"Department of Animal Science and Technology National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Seng","family":"Lin","sequence":"additional","affiliation":[{"name":"SynbioTech Incorporation  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2010Sun","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology National Taiwan University  Taipei Taiwan"},{"name":"Agricultural Biotechnology Research Center Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_2_8_3_1","first-page":"9072","volume":"20","author":"Firneisz G.","year":"2014","journal-title":"World J. 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