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Examinations were subsequently carried out, including the effects of RSV on muscle atrophy and muscle function, as well as on the signaling pathways related to protein degradation and MQC processes. The results show that RSV supplementation improves muscle atrophy and muscle function, attenuates the increase in ubiquitin and muscle RING\u2010finger protein\u20101 (MuRF\u20101), and simultaneously attenuates LC3\u2010II and cleaved caspase\u20103 in the skeletal muscle of diabetic mice. Moreover, RSV treatment of diabetic mice results in an increase in mitochondrial biogenesis and inhibition of the activation of mitophagy in skeletal muscle. RSV also protects skeletal muscle against excess mitochondrial fusion and fission in the diabetic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that RSV ameliorates diabetes\u2010induced skeletal muscle atrophy by modulating MQC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700941","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T10:48:05Z","timestamp":1522061285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Resveratrol Improves Muscle Atrophy by Modulating Mitochondrial Quality Control in STZ\u2010Induced Diabetic Mice"],"prefix":"10.1002","volume":"62","author":[{"given":"Dongtao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Shenzhen Hospital Southern Medical University  Shenzhen Guangdong 518000 China"},{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine  Shenzhen Guangdong 518033 China"},{"name":"Department of Nephrology Ruikang Affiliated Hospital Guangxi University of Chinese Medicine  Nanning 530011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine  Shenzhen Guangdong 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine  Shenzhen Guangdong 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangdong Key Laboratory for R&amp;D of Natural Drug Guangdong Medical College  Zhanjiang 524023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Shenzhen Hospital Southern Medical University  Shenzhen Guangdong 518000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine  Shenzhen Guangdong 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital Guangzhou University of Chinese Medicine  Shenzhen Guangdong 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-016-0880-y"},{"key":"e_1_2_7_4_1","first-page":"422","volume":"6","author":"Romanello V.","year":"2015","journal-title":"Front. 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