{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:19:54Z","timestamp":1790857194276,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["AGL2014\u201052911"],"award-info":[{"award-number":["AGL2014\u201052911"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>This study was undertaken to expand our insights into the mechanisms involved in the tolerance to resveratrol (RSV) that operate at system\u2010level in gut microorganisms and advance knowledge on new RSV\u2010responsive gene circuits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Whole genome transcriptional profiling was used to characterize the molecular response of <jats:italic>Lactobacillus plantarum<\/jats:italic> WCFS1 to RSV. DNA repair mechanisms were induced by RSV and responses were triggered to decrease the load of copper, a metal required for RSV\u2010mediated DNA cleavage, and H<jats:sub>2<\/jats:sub>S, a genotoxic gas. To counter the effects of RSV, <jats:italic>L. plantarum<\/jats:italic> strongly up\u2010 or downregulated efflux systems and ABC transporters pointing to transport control of RSV across the membrane as a key mechanism for RSV tolerance. <jats:italic>L. plantarum<\/jats:italic> also downregulated tRNAs, induced chaperones, and reprogrammed its transcriptome to tightly control ammonia levels. RSV induced a probiotic effector gene and a likely deoxycholate transporter, two functions that improve the host health status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data identify novel protective mechanisms involved in RSV tolerance operating at system level in a gut microbe. These insights could influence the way RSV is used for a better management of gut microbial ecosystems to obtain associated health benefits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201700992","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T01:25:15Z","timestamp":1521854715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Transcriptome\u2010Based Analysis in <i>Lactobacillus plantarum<\/i> WCFS1 Reveals New Insights into Resveratrol Effects at System Level"],"prefix":"10.1002","volume":"62","author":[{"given":"In\u00e9s","family":"Rever\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Bacteriana Instituto de Ciencia y Tecnolog\u00eda de los Alimentos y Nutrici\u00f3n (ICTAN\u2010CSIC)  28040 Madrid 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