{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:37:07Z","timestamp":1789799827987,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancers of the oropharyngeal tissues, oesophagus, stomach, and colorectum are amongst the most common causes of death from cancer throughout the world. Higher consumption of fruits and vegetables is thought to be protective, and cruciferous vegetables are of particular interest because of their unique role as a source of biologically active glucosinolate breakdown products. A literature review of primary studies and meta\u2010analyses indicates that higher consumption of cruciferous vegetables probably reduces the risk of colorectal and gastric cancers by approximately 8% and 19%, respectively. Some studies support the hypothesis that the protective effect against colorectal cancer is modified by genetic polymorphisms of genes regulating the expression of enzymes of the glutathione <jats:italic>S<\/jats:italic>\u2010transferase family, but due to contradictory findings the evidence is currently inconclusive. Despite these promising findings, future epidemiological research on the protective effects of cruciferous plants will depend critically upon accurate measurement of dietary exposure, both to the vegetables themselves, and to their active constituents. The development of sensitive chemical assays has facilitated the measurement of urinary excretion of isothiocyanate metabolites as an objective biomarker of intake, but sampling strategies need to be optimized in order to assess long\u2010term exposures at the population level.<\/jats:p>","DOI":"10.1002\/mnfr.201701000","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T01:05:31Z","timestamp":1521853531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Cruciferous Vegetables and Risk of Cancers of the Gastrointestinal Tract"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-4609","authenticated-orcid":false,"given":"Ian T.","family":"Johnson","sequence":"first","affiliation":[{"name":"Quadram Institute Bioscience  Norwich Research Park, Colney Lane Norwich NR4 7UA United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310912"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyv002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09958-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635589209514201"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051672"},{"key":"e_1_2_6_7_1","volume-title":"Food, Nutrition and the Prevention of Cancer: A Global Perspective","author":"WCRF\/AICR","year":"1997"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200128"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<967::AID-JSFA597>3.0.CO;2-V"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.01.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21384"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<1::AID-IJC1>3.0.CO;2-8"},{"key":"e_1_2_6_14_1","volume-title":"Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective","author":"WCRF\/AICR","year":"2007"},{"key":"e_1_2_6_15_1","first-page":"733","volume":"5","author":"Verhoeven D. 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