{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:34:10Z","timestamp":1760646850902,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["16\/2551\u20100000499\u20104"],"award-info":[{"award-number":["16\/2551\u20100000499\u20104"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Beneficial effects produced by polyphenolic compounds are used in the treatment of various diseases, including diabetes. Thus it is relevant to investigate the protective effect of lingonberry extract (LB) on the activities of nucleoside triphosphate diphosphohydrolase (NTPDase), 5\u2019\u2010nucleotidase (5\u2019\u2010NT), and adenosine deaminase (ADA); the density of A1, A2A, and P2\u00d77 receptors; production of reactive species (RS); and the levels of thiobarbituric acid reactive substances (TBARS) in the cerebral cortex of streptozotocin\u2010induced diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Animals were divided into five groups (<jats:italic>n<\/jats:italic>= 10): control\/saline; control\/LB 50 mg kg<jats:sup>\u22121<\/jats:sup>; diabetic\/saline; diabetic\/LB 25 mg kg<jats:sup>\u22121<\/jats:sup>; and diabetic\/LB 50 mg kg<jats:sup>\u22121<\/jats:sup>; and treated for 30 days. Our results demonstrate that the treatment with LB increased NTPDase activity in the diabetic\/LB 50 group compared to diabetic\/saline group. Western blot analysis showed that LB restored the density of purinergic receptors to the approximate values of the control\/saline group. An increase in the levels of RS and TBARS was observed in the diabetic\/saline group compared with the control\/saline group, and treatment with LB can prevent this increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that LB could reverse the modifications found in the diabetic state, suggesting that lingonberry may be a coadjuvant in the treatment of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800050","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T09:25:39Z","timestamp":1528709139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lingonberry Extract Provides Neuroprotection by Regulating the Purinergic System and Reducing Oxidative Stress in Diabetic Rats"],"prefix":"10.1002","volume":"62","author":[{"given":"Karine Paula","family":"Reichert","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa Chitolina","family":"Schetinger","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie Martins","family":"Gutierres","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Paula","family":"Pelinson","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiara","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di\u00e9ssica Padilha","family":"Dalenogare","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jucimara","family":"Baldissarelli","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Qu\u00edmicas Farmac\u00eauticas e de Alimentos Universidade Federal de Pelotas Pelotas RS 96160\u2010000 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thauan Faccin","family":"Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Maria","family":"Morsch","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecular Universidade Federal de Santa Maria Santa Maria RS 97105\u2010900 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0221-8"},{"key":"e_1_2_8_3_1","first-page":"159","volume":"490","author":"Brands A. M. A.","year":"2004","journal-title":"J. Pharmacol."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(98)00134-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00034-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","volume":"50","author":"Ralevic V.","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.08.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.08.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63569-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01574-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00140-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.10.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.1097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.01.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10058"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf103965b"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.02.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030479p"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-029"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.08.019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1919-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.11.014"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.12.036"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb12851.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007500424392"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb12832.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1361017"},{"key":"e_1_2_8_31_1","first-page":"315","volume-title":"Methods of Enzymatic Analysis","author":"Guist G.","year":"1984"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03247-5"},{"key":"e_1_2_8_33_1","first-page":"1575","volume":"65","author":"Myhre O.","year":"2003","journal-title":"Pharmacol."},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2012.09.004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.069"},{"journal-title":"Altern. Med.","year":"2014","author":"Eid H. M.","key":"e_1_2_8_39_1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01005-9"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm950661k"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.4.1531"},{"key":"e_1_2_8_43_1","first-page":"34","volume":"576","author":"Kuhad A.","year":"2007","journal-title":"J. Pharmacol."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(94)00124-D"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201800050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201800050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:11:41Z","timestamp":1751681501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201800050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":43,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/mnfr.201800050"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201800050","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"type":"print","value":"1613-4125"},{"type":"electronic","value":"1613-4133"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"2018-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800050"}}