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It is observed that the incubation with Phi or phr\u2010FPH result in lower levels of tumor necrosis factor \u03b1 and nitric oxide in macrophages stimulated with bacterial lipopolysaccharide + interferon\u2010\u03b3. Prophylactic and therapeutic treatments with Phi and phr\u2010FPH, respectively, greatly contribute to the prevention of weight loss and colon inflammation in colitic BALB\/c mice. T cell proliferation, expansion of TH1 and TH17 cells, and pro\u2010inflammatory cytokines are lower, whereas Treg cells are higher in spleen cell cultures from Phi\u2010treated mice. In addition, therapeutic phr\u2010FPH treatment is able to reduce the expansion of TH17 in splenic cell cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The consumption of phenolic and protein compounds extracted from flaxseeds has a protective effect on TNBS\u2010induced colitis, and may be useful in the control of other inflammatory disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800088","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T12:58:11Z","timestamp":1529672291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Intake of Protein Hydrolysates and Phenolic Fractions Isolated from Flaxseed Ameliorates TNBS\u2010Induced Colitis"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-5415","authenticated-orcid":false,"given":"Fernanda G. 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