{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:55:50Z","timestamp":1789379750839,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["12652"],"award-info":[{"award-number":["12652"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non\u2010digestible short\u2010 and long\u2010chain fructo\u2010oligosaccharides (scFOS\/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS\/lcFOS can also support the efficacy of OIT in a peanut allergy model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>After sensitization to peanut extract (PE) using cholera toxin, C3H\/HeOuJ mice are fed a 1% scFOS\/lcFOS or control diet and receive OIT (1.5 or 15 mg PE). Hereafter, mice are exposed to PE via different routes to determine the safety and efficacy of treatment in clinical outcomes, PE\u2010specific antibody production, and numbers of various immune cells. scFOS\/lcFOS increases short\u2010chain fatty acid levels in the caecum and reduce the acute allergic skin response and drop in body temperature after PE exposure. Interestingly, 15 mg and 1.5 mg OIT with scFOS\/lcFOS induce protection against anaphylaxis, whereas 1.5 mg OIT alone does not. OIT, with or without scFOS\/lcFOS, induces PE\u2010specific immunoglobulin (Ig) IgG and IgA levels and increases CD103+ dendritic cells in the mesenteric lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>scFOS\/lcFOS and scFOS\/lcFOS combined with low dose OIT are able to protect against a peanut\u2010allergic anaphylactic response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800369","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T09:35:08Z","timestamp":1534152908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse 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