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In this randomized, double\u2010blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80\u00a0mg kg<jats:sup>\u22121<\/jats:sup>), FVOO (500\u00a0mg kg<jats:sup>\u22121<\/jats:sup>), and FVOOT (500\u00a0mg kg<jats:sup>\u22121<\/jats:sup>; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat\u2010soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol\u2010enriched VOOs. These insights support the beneficial effects of OO and PC from different sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Novel therapeutic strategies should increase HDL\u2010cholesterol levels and enhance HDL functionality. The tailoring of phenol\u2010enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800456","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T11:47:43Z","timestamp":1530272863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cardiovascular Benefits of Phenol\u2010Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study"],"prefix":"10.1002","volume":"62","author":[{"given":"Anna","family":"Pedret","sequence":"first","affiliation":[{"name":"Eurecat Centre Tecnol\u00f2gic de Catalunya Unitat de Nutrici\u00f3 i Salut Functional Nutrition, Oxidation, and CVD Research Group (NFOC\u2010Salut)  43204 Reus Spain"},{"name":"Facultat de Medicina i 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