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After addition of the digests to TNF\u2010\u03b1 challenged Caco\u20102\/endothelial cocultures, intercellular adhesion molecule (ICAM)\u20101, IL\u20108, and monocyte chemoattractant protein\u20101 levels are significantly downregulated. Interestingly, Aronia juice treats digests from each colon compartment resulting in a stronger decrease of the ICAM\u20101 secretion (up to 73%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) compared to their corresponding placebo treated digests, thereby pointing to a polyphenol\u2010dependent effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aronia polyphenols modulate intestinal microbial composition, induce beneficial short chain fatty acid production, and prevent inflammatory stress in endothelial cells. This opens perspectives for the use of Aronia polyphenols as prebiotics in the context of intestinal and cardiovascular health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800607","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T20:51:24Z","timestamp":1537390284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Aronia (<i>Aronia melanocarpa<\/i>) Polyphenols Modulate the Microbial Community in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and Decrease Secretion of Proinflammatory Markers in a Caco\u20102\/endothelial Cell Coculture Model"],"prefix":"10.1002","volume":"62","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Food Technology Safety and Health Ghent University  9000 Ghent 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