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Unintentional weight loss (UWL) is a clinical feature of symptomatic HD subjects. To prevent UWL, a customized HD diet is designed and its impact on plasma miRNA HD footprint and neurological parameters is examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eleven participants are included, BMI\u00a0\u2264\u00a018 kg\u00a0m<jats:sup>\u20132<\/jats:sup> or UWL of 5% in 6 months or 10% in a year. Diet design is based on nutritional surveys and interviews of participants and caregivers and on published literature review. Twelve\u2010month dietary intervention, with follow\u2010up every 3 months, induces high diet adherence, which manages to curb UWL in all participants (73% gained weight). Noticeable increases in fat mass and leptin levels are obtained. The results also show significant decrease in the expression of 19 miRNAs, which are previously reported to be upregulated in HD\u2010patients versus healthy controls: revealing hsa\u2010miR\u2010338\u20103p, hsa\u2010miR\u2010128\u20103p, hsa\u2010miR\u201023a\u20103p, and hsa\u2010miR\u201024\u20103p as potential HD\u2010biomarkers. The diminished expression of hsa\u2010miR\u2010100\u20105p reflects the general maintenance of the functional status. Cognitive status is improved in six of 11 participants, while only three present better motor\u2010score values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A customized HD\u2010diet prevents UWL and modified miRNAs HD\u2010footprint. The normalization of miRNA values suggests its potentially use as HD\u2010biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800619","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T17:52:53Z","timestamp":1540489973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease"],"prefix":"10.1002","volume":"62","author":[{"given":"Miguel","family":"Aganzo","sequence":"first","affiliation":[{"name":"Division of Endocrinology Fundaci\u00f3n Jim\u00e9nez D\u00edaz  28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Teresa","family":"Montojo","sequence":"additional","affiliation":[{"name":"Department of Neurology Movement Disorders Unit Fundaci\u00f3n Jim\u00e9nez D\u00edaz  28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Carmen","family":"L\u00f3pez de Las Hazas","sequence":"additional","affiliation":[{"name":"Laboratory of Epigenetics of Lipid Metabolism Instituto Madrile\u00f1o de Estudios Avanzados (IMDEA)\u2010Alimentaci\u00f3n CEI UAM+CSIC  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asunci\u00f3n","family":"Mart\u00ednez\u2010Descals","sequence":"additional","affiliation":[{"name":"Department of Neurology Movement Disorders Unit Fundaci\u00f3n Jim\u00e9nez D\u00edaz  28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ricote\u2010Vila","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory Instituto de Investigaci\u00f3n Sanitaria\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS\u2010FJD)  UAM, Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Sanz","sequence":"additional","affiliation":[{"name":"Centros de Estudios Gen\u00e9ticcos ATG Medical  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Gonz\u00e1lez\u2010Peralta","sequence":"additional","affiliation":[{"name":"Centros de Estudios Gen\u00e9ticcos ATG Medical  Madrid Spain"},{"name":"Escuela Superior de Ciencias Experimentales y Tecnolog\u00eda. 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