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At present, people who suffer from celiac disease have to follow a gluten\u2010exclusion diet throughout their lives. Compliance to this restrictive diet is demanding and the development of alternative strategies has become urgent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this context, it is found that the biocompatible aminopolysaccharide chitosan imposes a different gluten reorganization after gluten redox reaction producing in situ mechanically interlocked supramolecular assemblies between gluten and chitosan. These new structures result in the decrease of gluten digestibility, tissue transglutaminase deamidation activity, and interferon\u2010\u03b3 production in intestinal T cell lines generated from biopsy specimens of celiac disease patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, the results demonstrate the potential of this research avenue to celiac disease is problematic, as the reorganization of gluten proteins to a novel supramolecular architecture shows a positive impact on known pathogenesis mechanisms of the disease. At present, the only therapy for celiac disease is adherence to a gluten\u2010free diet. Here, it is shown that chitosan\u2010imposed gluten reorganization to an interlocked self\u2010assembled supramolecular architecture reduces gluten digestibility, R5\u2010reactivity, tissue transglutaminase deamidation activity, and its capacity to stimulate a T\u2010cell\u2010mediated immune response in celiac disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800646","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T09:42:34Z","timestamp":1538818954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In Situ Gluten\u2013Chitosan Interlocked Self\u2010Assembled Supramolecular Architecture Reduces T\u2010Cell\u2010Mediated Immune Response to Gluten in Celiac Disease"],"prefix":"10.1002","volume":"62","author":[{"given":"Miguel","family":"Ribeiro","sequence":"first","affiliation":[{"name":"CQ\u2010VR, Chemistry Research Centre, Food and Wine Chemistry Lab. Chemistry Department University of Tr\u00e1s\u2010os\u2010Montes and Alto Douro  5000\u2013801 Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Picascia","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry\u2010CNR  Via Pietro Castellino, 111 80131 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larbi","family":"Rhazi","sequence":"additional","affiliation":[{"name":"UniLaSalle Unit\u00e9 de recherche \u201cTransformations &amp; Agro\u2010Ressources\u201d  19 rue Pierre Waguet \u2013 BP 30313 F\u201060026 Beauvais Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Gianfrani","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry\u2010CNR  Via Pietro Castellino, 111 80131 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Maria","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Unit of Genetics, Department of Biotechnology \u2013 Plant Biology. 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