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Accompanying these changes, treatment with 6\u2010gingerol attenuates excessive triglyceride accumulation, enhances mitochondrial function, and promotes a transition from a fast\u2010 to slow\u2010fiber type and muscle oxidative metabolism in the red gastrocnemius of ageing rats. More importantly, 6\u2010gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC\u20101\u03b1 in vivo and in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>6\u2010Gingerol may improve ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats. These effects rely, at least in part, on the elevated plasma adiponectin concentration and muscle AdipoR1 level to dually activate the AMPK\/PGC\u20101\u03b1 signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800649","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T14:23:28Z","timestamp":1545402208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["6\u2010Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK\/PGC\u20101\u03b1 Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1"],"prefix":"10.1002","volume":"63","author":[{"given":"Li","family":"Liu","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases College of Traditional Chinese Medicine Chongqing 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