{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:36:32Z","timestamp":1790775392853,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571841"],"award-info":[{"award-number":["31571841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700301"],"award-info":[{"award-number":["31700301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Dietary methionine restriction (MR) promotes multifaceted health benefits<\/jats:bold>\n                      . Moreover, lower rate of protein synthesis by dietary MR is associated with life span extension. The goal of this work is to explore how dietary MR would affect protein metabolism in a mouse model of high\u2010fat\u2010diet\u2010induced obesity (DIO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      DIO mice (male C57BL\/6) are subjected to dietary MR for 22\u00a0weeks. High\u2010throughput sequencing technology, qRT\u2010PCR analysis, and the dual luciferase reporter assay are performed to verify that MiR\u2010328\u20103p directly targets cystathionine \u03b3\u2010lyase (CSE) to modulate endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S production. Moreover, indicators of endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S, fractional synthesis rate (FSR), fractional growth rate (FGR), fractional degradation rate (FDR), and protein retention efficiency (PRE) are analyzed. MR results in an increase in endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S to relieve oxidative stress and ER stress to improve protein homeostasis and metabolic efficiency in DIO mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Results show that dietary MR increases endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S production via miR\u2010328\u20103p. Furthermore, these results suggest the potential involvement of endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S on the efficiency of protein metabolism in dietary MR.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201800735","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T11:32:38Z","timestamp":1543923158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dietary Methionine Restriction Upregulates Endogenous H\n                    <sub>2<\/sub>\n                    S via miR\u2010328\u20103p: A Potential Mechanism to Improve Liver Protein Metabolism Efficiency in a Mouse Model of High\u2010fat\u2010diet\u2010induced Obesity"],"prefix":"10.1002","volume":"63","author":[{"given":"Guoqing","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 P. 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