{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:54:41Z","timestamp":1783461281682,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330003"],"award-info":[{"award-number":["81330003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703217"],"award-info":[{"award-number":["81703217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits anti\u2010oxidative and anti\u2010inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure\u2010overload\u2010induced cardiac hypertrophy and the underlying mechanism remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Primary cardiomyocyte hypertrophy is stimulated with angiotensin II (Ang II). Cardiac hypertrophic remodeling is induced in mice by transverse aortic constriction (TAC). Myocardial function is evaluated by echocardiographic and hemodynamic analyses, while cardiac tissues are analyzed by histological staining. It is observed that GA significantly decreases Ang II\u2010induced increases in cardiomyocyte size in vitro. Administration of GA in mice markedly improves TAC\u2010induced cardiac dysfunction and attenuates pathological changes, including cardiac myocyte hypertrophy, fibrosis, inflammation, and oxidative stress. Mechanistically, GA inhibits ULK1 and activates autophagy, which induces the degradation of EGFR, gp130, and calcineurin A, thereby inhibiting the downstream signaling cascades (AKT, ERK1\/2, JAK2\/STAT3, and NFATc1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results demonstrate for the first time that GA prevents myocardial hypertrophy and dysfunction via an autophagy\u2010dependent mechanism. Thus, GA represents a promising therapeutic candidate for treating cardiac hypertrophy and heart failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800807","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T19:47:23Z","timestamp":1544125643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure"],"prefix":"10.1002","volume":"63","author":[{"given":"Xiao","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene School of Public Health Dalian Medical University  Dalian 116044 China"},{"name":"Department of Cardiology Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University  Dalian 116011 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