{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:41:27Z","timestamp":1787064087407,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008975","name":"University of Massachusetts Amherst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2014\u201067017\u201021762"],"award-info":[{"award-number":["2014\u201067017\u201021762"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["MAS00514"],"award-info":[{"award-number":["MAS00514"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>\n                      The previous study shows that obesity\u2010promoted inflammation is responsible for the activation of the intestinal tumorigenic\n                      <jats:italic>Wnt<\/jats:italic>\n                      \u2010signaling. The present study aims to test a dietary strategy, dietary supplementation with a high dose of vitamin D (VD) or its combination with sulforaphane (SFN) to inhibit intestinal inflammation and obesity\u2010associated tumorigenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        Apc\n                        <jats:sup>1638N<\/jats:sup>\n                      <\/jats:italic>\n                      mice are randomly divided into four groups:\n                      <jats:italic>LF<\/jats:italic>\n                      , a low\u2010fat diet (10 kcal% fat) with 200 IU VD;\n                      <jats:italic>HF<\/jats:italic>\n                      , a high\u2010fat diet (60 kcal% fat) with 200 IU VD;\n                      <jats:italic>HFD<\/jats:italic>\n                      , a high\u2010fat diet with 5000 IU VD; and\n                      <jats:italic>HFDS<\/jats:italic>\n                      , a high\u2010fat diet plus 5000 IU VD and 0.23 g SFN per \u22484000 kcal. VD administration decreased tumor incidence and size, and the co\u2010administration with SFN (HFDS) magnified the effects. Inflammation and\n                      <jats:italic>Wnt<\/jats:italic>\n                      \u2010signaling are suppressed by VD. The addition of SFN decreased the activity of histone deacetylase (HDAC) and increased autophagy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The administration of VD, at 5000 IU level, exerts an anti\u2010inflammatory property and leads to suppressed intestinal\n                      <jats:italic>Wnt<\/jats:italic>\n                      \u2010signaling and tumorigenesis in obese mice. The molecular function of SFN on a high dose of VD supplementation, although displayed on the inhibition of HDAC and the activation of autophagy, needs further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201800824","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T09:55:42Z","timestamp":1542448542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Prevention of a High Dose of Vitamin D or Its Combination with Sulforaphane on Intestinal Inflammation and Tumorigenesis in\n                    <i>\n                      Apc\n                      <sup>1638N<\/sup>\n                    <\/i>\n                    Mice Fed a High\u2010Fat Diet"],"prefix":"10.1002","volume":"63","author":[{"given":"Jinchao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armina\u2010Lyn M.","family":"Frederick","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"},{"name":"Department of Gastroenterology Shengjing Hospital China Medical University  Shenyang Liaoning 110004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"},{"name":"Department of Molecular Medicine Hunan University  Changsha Hunan 410006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Massachusetts  Amherst MA 01002 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-055X","authenticated-orcid":false,"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts  Amherst MA 01002 USA"},{"name":"Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University  Boston MA 02153 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.06.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.54"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-017-0383-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11888-014-0238-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.07.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2011.594208"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2115"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.3506"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds601"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.113332"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks959"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102412"},{"key":"e_1_2_7_14_1","first-page":"227","volume":"232","author":"Myzak M. C.","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00190.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203036"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(96)00041-8"},{"key":"e_1_2_7_18_1","first-page":"5713","volume":"58","author":"Yang K.","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.6.1114"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.07.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12101"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.06.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.5.1475"},{"key":"e_1_2_7_24_1","first-page":"607","volume":"31","author":"Garland C. F.","year":"2011","journal-title":"Anticancer Res."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.09.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010804"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.03.037"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.04.005"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0696-x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0139"},{"key":"e_1_2_7_31_1","first-page":"3381","volume":"30","author":"Kanematsu S.","year":"2010","journal-title":"Anticancer Res."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3060"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_7_35_1","first-page":"223","volume":"32","author":"Grant W. B.","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0289"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055222"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2006.11.004"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5500"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0105"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7678183"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.267"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500409"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.12.035"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.1.176"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.3.508S"},{"key":"e_1_2_7_48_1","first-page":"607","volume":"31","author":"Garland C. F.","year":"2011","journal-title":"Anticancer Res."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.09.003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2196"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.247"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm094"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00065.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22224"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36215"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207772"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204269"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm913"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.03.081"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.105"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu037"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023524"},{"key":"e_1_2_7_63_1","first-page":"77","volume":"11","author":"Tong W. M.","year":"1999","journal-title":"Oncol. Res."},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1112"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1326"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi265"},{"key":"e_1_2_7_67_1","first-page":"4505","volume":"9","author":"Xu L.","year":"2016","journal-title":"Int. J. Clin. Exp. Patho."},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.3.1.5736"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.018"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801716200"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615015114"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.036"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1502-4"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201800824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201800824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.201800824","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/mnfr.201800824","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201800824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:18:54Z","timestamp":1694711934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201800824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/mnfr.201800824"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201800824","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800824"}}