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Mechanistic hypotheses include alterations in oxidative status, gut microbiome, fat deposition, and low\u2010grade inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>For 2 weeks, 40 rats consumed a diet high in white or red meat (chicken\u2010based or beef\u2010based cooked mince, respectively), and containing corn starch or sucrose in a 2 \u00d7 2 factorial design. Lard was mixed with lean chicken or beef to obtain comparable dietary fatty acid profiles. Beef (vs chicken)\u2010fed rats had higher lipid oxidation products (malondialdehyde, 4\u2010hydroxy\u20102\u2010nonenal, and hexanal) in stomach content and blood, and lower blood glutathione. Sucrose (vs corn starch)\u2010fed rats showed increased blood lipid oxidation products and glutathione peroxidase activity, higher liver weight and malondialdehyde concentrations, and mesenterial and retroperitoneal fat accumulation. Beef\u2013sucrose\u2010fed rats had increased cardiac weight, suggesting pathophysiological effects on the cardiovascular system. The colonic microbiome of beef\u2013sucrose\u2010fed rats showed an outgrowth of the sulfate\u2010reducing family of the Desulfovibrionaceae, and lower abundance of the<jats:italic>Lactobacillus<\/jats:italic>genus, indicating intestinal dysbiosis. Blood C\u2010reactive protein, a marker for inflammation, was not different among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consumption of a cooked beef\u2010based meat product with sucrose increased oxidative stress parameters and promoted cardiac hypertrophy and intestinal dysbiosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201800962","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T16:09:45Z","timestamp":1541002185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Combined Consumption of Beef\u2010Based Cooked Mince and Sucrose Stimulates Oxidative Stress, Cardiac Hypertrophy, and Colonic Outgrowth of Desulfovibrionaceae in Rats"],"prefix":"10.1002","volume":"63","author":[{"given":"Thomas","family":"Van Hecke","sequence":"first","affiliation":[{"name":"Laboratory for Animal Nutrition and Animal Product Quality Department of 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