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Patients with hypertension frequently have a significant deficiency of the antioxidant CoQ10. Furthermore, reactive oxygen species are overproduced in the nucleus tractus solitarii (NTS) during the cardiovascular regulation of hypertension in vivo. However, the molecular mechanisms by which CoQ10 modulates cardiovascular functions in the NTS are unclear. In this study, the effects of CoQ10 on superoxide generation, downstream NO signaling in the NTS, and blood pressure were evaluated in rats with fructose\u2010induced hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Treatment with oral CoQ10 for 4 weeks abolished nicotinamide adenine dinucleotide phosphate\u2010oxidase (NADPH oxidase) activation, decreased p38 phosphorylation, and increased superoxide dismutase 2 production in the NTS of fructose\u2010fed rats. The serum levels of uric acid decrease in response to CoQ10 treatment in fructose\u2010fed rats. Oral CoQ10 reduced blood pressure by inducing Akt and nNOS phosphorylation in NTS of fructose\u2010induced hypertensive rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral CoQ10 decreases blood pressure by negatively regulating fructose\u2010induced NADPH oxidase levels, abolishing ROS generation, reducing p38 phosphorylation, and enhancing the Akt\u2010nNOS pathway in the NTS. These results support the beneficial effects of CoQ10 in oxidative stressassociated hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201801042","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T22:31:01Z","timestamp":1548282661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt\u2010nNOS Signaling in the Nucleus Tractus Solitarii in Rats"],"prefix":"10.1002","volume":"63","author":[{"given":"Hsin\u2010Hung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital  Kaohsiung 81362 Taiwan"},{"name":"Yuh\u2010Ing Junior College of Health Care &amp; Management  Kaohsiung 80776 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Chen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Kaohsiung Veterans General Hospital  Kaohsiung 81362 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital  Kaohsiung 81362 Taiwan"},{"name":"Yuh\u2010Ing Junior College of Health Care &amp; Management  Kaohsiung 80776 Taiwan"},{"name":"Department of Physical Therapy Shu\u2010Zen Junior College of Medicine and Management  Kaohsiung 82144 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yu","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung 80708 Taiwan"},{"name":"Division of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University  Kaohsiung 80708 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu\u2010Yi","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital  Kaohsiung 81362 Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010sen University  Kaohsiung 80424 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Cardiology Kaohsiung Municipal United Hospital  Kaohsiung 80457 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwo\u2010Ching","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kaohsiung Medical University Hospital  Kaohsiung 80708 Taiwan"},{"name":"Department of Anesthesiology Faculty of Medicine College of Medicine Kaohsiung Medical University  Kaohsiung 80708 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Jiunn","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital  Kaohsiung 81362 Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010sen University  Kaohsiung 80424 Taiwan"},{"name":"Department of Medical Research China Medical University Hospital China Medical University  Taichung 40447 Taiwan"},{"name":"Department of Pharmacology National Defense Medical Center  Taipei 11490 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"e13","volume":"71","author":"Whelton P. 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