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Zinc is important in affecting signal transduction and, in particular, in the development and integrity of the immune system, where it affects both innate and adaptive immune responses. The eye, especially the retina\u2010choroid complex, has an unusually high concentration of zinc compared to other tissues. The highest amount of zinc is concentrated in the retinal pigment epithelium (RPE) (RPE\u2010choroid, 292 \u00b1 98.5\u00a0\u00b5g g<jats:sup>\u22121<\/jats:sup> dry tissue), followed by the retina (12362.2\u00a0\u00b5g g<jats:sup>\u22121<\/jats:sup> dry tissue). The interplay between zinc and inflammation has been explored in other parts of the body but, so far, has not been extensively researched in the eye. Several lines of evidence suggest that ocular zinc concentration decreases with age, especially in the context of age\u2010related disease. Thus, a hypothesis that retinal function could be modulated by zinc nutrition is proposed, and subsequently trialled clinically. In this review, the distribution and the potential role of zinc in the retina\u2010choroid complex is outlined, especially in relation to inflammation and immunity, and the clinical studies to date are summarized.<\/jats:p>","DOI":"10.1002\/mnfr.201801049","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T04:04:21Z","timestamp":1559275461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Zinc Nutrition and Inflammation in the Aging Retina"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9115-1220","authenticated-orcid":false,"given":"Rosie","family":"Gilbert","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust  City Road London EC1V 2PD UK"},{"name":"UCL Institute of Ophthalmology  Bath Street London EC1V 2EL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Science Queen's University Belfast  97 Lisburn Road Belfast BT9 7BL Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Lengyel","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology  Bath Street London EC1V 2EL UK"},{"name":"School of Medicine Dentistry and Biomedical Science Queen's University Belfast  97 Lisburn Road Belfast BT9 7BL Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Emri","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Science Queen's University Belfast  97 Lisburn Road Belfast BT9 7BL Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(85)80007-4"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2006.01.006"},{"key":"e_1_2_12_3_1","unstructured":"FAO\/WHO Human Vitamin and Mineral Requirements \u2013 Zinc Report of a Joint FAO\/WHO Expert Consultation Agriculture and Consumer Protection Department Food and Agriculture Organization UN2001 Ch. 16."},{"key":"e_1_2_12_4_1","unstructured":"Health Education Authority1996."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1417"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0510521"},{"key":"e_1_2_12_8_1","first-page":"142","volume":"1","author":"Galin M. 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