{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:36:19Z","timestamp":1770510979122,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872102"],"award-info":[{"award-number":["30872102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>To compare the effects of supplementary eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) versus \u03b1\u2010linolenic acid (ALA) on lipid profiles, inflammatory status, and fatty acid composition of peripheral blood mononuclear cells (PBMCs) in hypercholesterolemic adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A randomized, controlled, double\u2010blind trial is conducted to examine the effects of consumption of control oil, 4.2\u00a0g\/d ALA, 7.2\u00a0g\/d ALA, 1.8\u00a0g\/d DHA+EPA, or 3.6\u00a0g\/d EPA+DHA for 12\u00a0weeks on lipid profiles, fatty acid composition of PBMCs and in vitro production of interleukin\u20106 (IL\u20106) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) by PBMCs in 123 subjects with hypercholesteremia. After the intervention, subjects who receive a low and high dose of DHA\/EPA experience 11.99% and 15.78% decreases in triglycerides which is significantly different from that of the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). The in vitro study indicates that supplementation of high\u2010dose DHA+EPA induces the greatest decrease of IL\u20106 production by PBMCs relative to other groups (<jats:italic>p<\/jats:italic> = 0.046). ALA intervention significantly increases the PBMCs composition of ALA but not EPA\/DHA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EPA+DHA, but not ALA, improves lipids and inflammation status in hypercholesterolemic adults. Supplementation of ALA does not increase the PBMCs composition of EPA\/DHA in middle\u2010aged to elderly Chinese.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201801157","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T10:29:16Z","timestamp":1553250556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"63","author":[{"given":"Quan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene School of Public Health Guangzhou Medical University  Guangzhou 510182 P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Food School of Public Health Sun Yat\u2010Sen University  Guangzhou 510080 P. R. 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