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The aim of this study was to isolate and identify angiotensin I\u2010converting enzyme inhibitory (ACEI) peptides from chicken foot hydrolysate Hpp11 and to test their antihypertensive properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Peptides are separated into fractions according to their molecular size and hydrophobicity by ultrafiltration and RP\u2010HPLC, respectively. Subsequent peptide identification in the two fractions that present the highest ACEI activities is carried out by HPLC\u2010MS. Ten of the identified peptides are synthesized and five of them show ACEI (IC<jats:sub>50<\/jats:sub>) values lower than 100\u00a0\u00b5<jats:sc>m<\/jats:sc>. The antihypertensive effects of these ACEI peptides after oral administration is evaluated in spontaneously <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/hypertensive\">hypertensive<\/jats:ext-link> rats. The peptides AVFQHNCQE and QVGPLIGRYCG exhibit antihypertensive activity when administered at an oral dose of 10 mg kg<jats:sup>\u22121<\/jats:sup> body weight. The maximal decrease in systolic blood pressure is recorded 6 h after their administration (\u221225.07 \u00b1 4.21 and \u221210.94 \u00b1 1.96 mmHg, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that AVFQHNCQE and QVGPLIGRYCG could be used as functional ingredients with antihypertensive effects, although it would be necessary to perform bioavailability and clinical studies to demonstrate their efficiency in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201801176","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T10:22:13Z","timestamp":1553854933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Novel Antihypertensive Peptides Derived from Chicken Foot Proteins"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6468-3088","authenticated-orcid":false,"given":"Francisca I.","family":"Bravo","sequence":"first","affiliation":[{"name":"Universitat Rovira i Virgili Department of Biochemistry and Biotechnology Nutrigenomics Research Group C\/ Marcel.l\u00ed Domingo  n<sup>o<\/sup> 1 Tarragona 43007 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mas\u2010Capdevila","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili Department of Biochemistry and Biotechnology Nutrigenomics Research Group C\/ Marcel.l\u00ed Domingo  n<sup>o<\/sup> 1 Tarragona 43007 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Margalef","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili Department of Biochemistry and Biotechnology Nutrigenomics Research Group C\/ Marcel.l\u00ed Domingo  n<sup>o<\/sup> 1 Tarragona 43007 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Arola\u2010Arnal","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili Department of Biochemistry and Biotechnology Nutrigenomics Research Group C\/ Marcel.l\u00ed Domingo  n<sup>o<\/sup> 1 Tarragona 43007 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Muguerza","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili Department of Biochemistry and Biotechnology Nutrigenomics Research Group C\/ Marcel.l\u00ed Domingo  n<sup>o<\/sup> 1 Tarragona 43007 Spain"},{"name":"EURECAT\u2010Technology Centre of Catalonia Technological Unit of Nutrition and Health Avda. 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