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For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin\u00a0B<jats:sub>12<\/jats:sub> intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin\u00a0B<jats:sub>12<\/jats:sub> intake for infants, children, and adolescents range from 0.5 to 4.0\u00a0\u00b5g\u00a0d<jats:sup>\u22121<\/jats:sup>. For adults, the estimated values are set at 4.0\u00a0\u00b5g\u00a0d<jats:sup>\u22121<\/jats:sup>, and for pregnant and lactating women, they are set at 4.5 and 5.5\u00a0\u00b5g\u00a0d<jats:sup>\u22121<\/jats:sup>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the data of several vitamin\u00a0B<jats:sub>12<\/jats:sub> status biomarkers studies, the reference value for vitamin B<jats:sub>12<\/jats:sub> intake for adults is raised from 3.0 to 4.0 \u00b5g\u00a0d<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201801178","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T13:54:55Z","timestamp":1547819695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Revised D\u2010A\u2010CH\u2010Reference Values for the Intake of Vitamin B<sub>12<\/sub>: Prevention of Deficiency and Beyond"],"prefix":"10.1002","volume":"63","author":[{"given":"Alexander","family":"Str\u00f6hle","sequence":"first","affiliation":[{"name":"Institute of Food Science and Human Nutrition Leibniz University Hannover  Am Kleinen Felde 30 30167 Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margrit","family":"Richter","sequence":"additional","affiliation":[{"name":"German Nutrition Society (DGE)  Godesberger Allee 18 53175 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Gonz\u00e1lez\u2010Gross","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance Universidad Polit\u00e9cnica de Madrid  c\/ Mart\u00edn Fierro 7 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Neuh\u00e4user\u2010Berthold","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Science Justus\u2010Liebig\u2010University  Goethestrasse 55 35390 Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Vienna  Althanstra\u00dfe 14 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Leschik\u2010Bonnet","sequence":"additional","affiliation":[{"name":"German Nutrition Society (DGE)  Godesberger Allee 18 53175 Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Egert","sequence":"additional","affiliation":[{"name":"German Nutrition Society (DGE)  Godesberger Allee 18 53175 Bonn Germany"},{"name":"Institute of Nutritional Medicine University of Hohenheim  Fruwirthstr. 12 70599 Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the German Nutrition Society (DGE)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_10_1_1","unstructured":"Deutsche Gesellschaft f\u00fcr Ern\u00e4hrung \u00d6sterreichische Gesellschaft f\u00fcr Ern\u00e4hrung Schweizerische Gesellschaft f\u00fcr Ern\u00e4hrung(Eds.) 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