{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:51:50Z","timestamp":1792263110738,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["201770E081"],"award-info":[{"award-number":["201770E081"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Dietary polyphenols may protect against breast cancer. However, it is unknown whether polyphenols reach human malignant breast tumors in molecular forms and(or) at concentrations likely to act against cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Ninteen breast cancer patients consumed three capsules daily from biopsy\u2010confirmed diagnosis to surgery (6\u00a0\u00b1\u00a02 days). The capsules contained pomegranate, orange, lemon, olive, cocoa, and grapeseed extracts plus resveratrol, providing 37 different phenolics (473.7 mg), theobromine and caffeine (19.7 mg). A total of 101 metabolites are identified in urine, 69 in plasma, 39 in normal (NT), and 33 in malignant (MT) tissues by UPLC\u2010ESI\u2010QTOF\u2010MS. Eight control patients did not consume extracts. Phenolic\u2010derived metabolites in MT and NT are mainly glucuronidated and(or) sulfated. Some representative metabolites detected in MT (median and range, pmol g<jats:sup>\u22121<\/jats:sup>) are urolithin\u2010A\u20103\u2010<jats:italic>O<\/jats:italic>\u2010glucuronide (26.2; 3.2\u221266.5), 2,5\u2010dihydroxybenzoic acid (40.2; 27.7\u221252.2), resveratrol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010sulfate (86.4; 7.8\u2212224.4), dihydroresveratrol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010glucuronide (109.9; 10.3\u2212229.4), and theobromine (715.0; 153.9\u22123,216). Metabolites, as detected in breast tissues, do not exert antiproliferative or estrogenic\/antiestrogenic activities in MCF\u20107 breast cancer cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study that describes the metabolic profiling of dietary phenolics and methylxanthines in MT and NT comprehensively. Although phase\u2010II conjugation might hamper a direct anticancer activity, long\u2010term tumor\u2010senescent chemoprevention cannot be discarded.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201801239","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:56:29Z","timestamp":1548734189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients"],"prefix":"10.1002","volume":"63","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"\u00c1vila\u2010G\u00e1lvez","sequence":"first","affiliation":[{"name":"Laboratory of Food &amp; Health Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS\u2010CSIC Campus de Espinardo  30100 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Garc\u00eda\u2010Villalba","sequence":"additional","affiliation":[{"name":"Laboratory of Food &amp; Health Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS\u2010CSIC Campus de Espinardo  30100 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mart\u00ednez\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Reina Sof\u00eda University Hospital Service of Anatomical Pathology  Avda. 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