{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:14:05Z","timestamp":1781014445051,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["315069\u20103"],"award-info":[{"award-number":["315069\u20103"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1B07041857"],"award-info":[{"award-number":["2018R1D1A1B07041857"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Obesity and diabetes are major public health problems and are emerging as pandemics. Considerable evidence suggests that pear fruit consumption is associated with a lower risk of obesity\u2010related complications. Thus, the present study is conducted to investigate the therapeutic potential of pear extract (PE) for reversing obesity and associated metabolic complications in high\u2010fat diet\u2010induced obese mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Obesity is induced in male C57BL\/6 mice fed a high\u2010fat diet for 11 weeks. After the first 6 weeks on the diet, obese mice are administered vehicle or PE for 5 weeks. PE treatment decreases body weight gain, expands white adipose tissue (WAT), and causes hepatic steatosis in obese mice, as well as inhibits adipogenesis and lipogenesis. Impaired glucose tolerance and insulin resistance are improved by PE. In addition, PE reduces macrophage infiltration and expression of pro\u2010inflammatory genes and deactivates mitogen\u2010activated protein kinases in WAT. Finally, malaxinic acid is identified as an active component responsible for the anti\u2010obesity effects of PE in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrate that PE supplementation ameliorates diet\u2010induced obesity and associated metabolic complications and suggest the health\u2010beneficial effects of both pear fruits and malaxinic acid in counteracting these diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201801347","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:23:57Z","timestamp":1556673837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pear Extract and Malaxinic Acid Reverse Obesity, Adipose Tissue Inflammation, and Hepatosteatosis in Mice"],"prefix":"10.1002","volume":"63","author":[{"given":"Xuan T.","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Animal Science Chonnam National University  Gwangju 61186 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy T. P.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Animal Science Chonnam National University  Gwangju 61186 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Jong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Animal Science Chonnam National University  Gwangju 61186 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"Research Group of Natural Materials and Metabolism Korea Food Research Institute  Wanju\u2010gun Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju 61186 Republic of 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