{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:48:43Z","timestamp":1791650923875,"version":"4.3.4"},"reference-count":240,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["289108 (Total Diet Study Exposure)"],"award-info":[{"award-number":["289108 (Total Diet Study Exposure)"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Manganese is both an essential nutrient and a potential neurotoxicant. Therefore, the question arises whether the dietary manganese intake in the German population is on the low or high side. Results from a pilot total diet study in Germany presented here reveal that the average dietary manganese intake in the general population in Germany aged 14\u201380 years is about 2.8 mg day<jats:sup>\u22121<\/jats:sup> for a person of 70 kg body weight. This exposure level is within the intake range of 2\u20135 mg per person and day as recommended by the societies for nutrition in Germany, Austria, and Switzerland. No information on the dietary exposure of children in Germany can be provided so far. Although reliable information on health effects related to oral manganese exposure is limited, there is no indication from the literature that these dietary intake levels are associated with adverse health effects either by manganese deficiency or excess. However, there is limited evidence that manganese taken up as a highly bioavailable bolus, for example, uptake via drinking water or food supplements, could pose a potential risk to human health\u2014particularly in certain subpopulations\u2014when certain intake amounts, which are currently not well defined, are exceeded.<\/jats:p>","DOI":"10.1002\/mnfr.201900065","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T13:45:13Z","timestamp":1560951913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Dietary Manganese Exposure in the Adult Population in Germany\u2014What Does it Mean in Relation to Health Risks?"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-4045","authenticated-orcid":false,"given":"Benjamin","family":"Sachse","sequence":"first","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elena","family":"Kolbaum","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Exposure  12277 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Ziegenhagen","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Andres","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Berg","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Exposure  12277 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Ildico","family":"Hirsch\u2010Ernst","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kappenstein","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Chemicals and Product Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Chemicals and Product Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"R\u00f6hl","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"},{"name":"State Agency for Social Services Schleswig\u2010Holstein (LAsD) Department of Environmental Health Protection  24105 Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Lindtner","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Exposure  12277 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Lampen","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"German Federal Institute for Risk Assessment (BfR) Department of Food Safety  10589 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"ATSDR (US Department of Health and Human Services: Agency for Toxic Substances and Disease Registry). Toxicological Profile for Manganese2012.https:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp151.pdf."},{"key":"e_1_2_9_2_1","volume-title":"Manganese and its Role in Biological Processes","author":"Sigel A.","year":"2000"},{"key":"e_1_2_9_3_1","first-page":"34","volume":"22","author":"Freeland\u2010Graves J. H.","year":"2015","journal-title":"Issues in Toxicology"},{"key":"e_1_2_9_4_1","first-page":"3419","volume":"11","author":"EFSA (European Food Safety Authority: Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA))","year":"2013","journal-title":"EFSA Journal"},{"key":"e_1_2_9_5_1","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","author":"IOM (Institute of Medicine). Chapter 10: Manganese","year":"2001"},{"key":"e_1_2_9_6_1","unstructured":"DACH. Referenzwerte f\u00fcr die N\u00e4hrstoffzufuhr DGE (Deutsche Gesellschaft f\u00fcr Ern\u00e4hrung) \u00d6GE (\u00d6sterreichische Gesellschaft f\u00fcr Ern\u00e4hrung) SGE (Schweizerische Gesellschaft f\u00fcr Ern\u00e4hrung). 2. Auflage 3. aktualisierte Ausgabe;2017."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071714-034419"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2741\/4665"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.1.170"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(91)90075-G"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.1.37"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.9.2849"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/121.5.711"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1986.tb02708.x"},{"key":"e_1_2_9_16_1","first-page":"65","volume":"4","author":"Sandstrom B.","year":"1990","journal-title":"J. Trace Elem. Electrolytes Health Dis."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2017.02.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802168-2.00030-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050085"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020702213099"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1038\/41343"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9130-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00079K"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.10.1000"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.6.949"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.6.1065"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.5.984"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1991.10718124"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050380"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/85.7.1217"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19890143"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(97)80032-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.782581"},{"key":"e_1_2_9_31_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bk-1987-0354.ch002","volume-title":"Nutritional Bioavailability of Manganese, ACS Symposium Series","author":"L\u00f6nnerdal B.","year":"1987"},{"key":"e_1_2_9_31_3","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19860009"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.3.395"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.3.450"},{"key":"e_1_2_9_34_1","first-page":"355","volume":"22","author":"Hoet P.","year":"2015","journal-title":"Issues Toxicol."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2006.08.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2010.12.004"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2007.06.038"},{"key":"e_1_2_9_36_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2012.01.002"},{"key":"e_1_2_9_36_4","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-13-87"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0223-1"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013000839"},{"key":"e_1_2_9_37_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.07.002"},{"key":"e_1_2_9_37_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2010.12.006"},{"key":"e_1_2_9_37_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2010.03.006"},{"key":"e_1_2_9_37_6","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9782-9"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2003.11.002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(11)80003-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0869-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(03)00058-5"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.08.023"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31819b93c0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2903\/sp.efsa.2012.EN-284"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2008.03.007"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2005.01.084"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2009.01648.x"},{"key":"e_1_2_9_45_3","doi-asserted-by":"publisher","DOI":"10.1065\/uwsf2004.02.072"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-196302000-00002"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13170"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxx041"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.002"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.003"},{"key":"e_1_2_9_49_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-0010-6"},{"key":"e_1_2_9_50_1","first-page":"8","volume":"59","author":"Tuschl K.","year":"2017","journal-title":"Dev. Med. Child Neurol."},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11601"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9526-x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.01.017"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.01.018"},{"key":"e_1_2_9_52_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005628"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv252"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-97"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.09.003"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13442"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.03.002"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0030-x"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-016-0099-0"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(76)90218-X"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn231"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-202-43518"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.2.489"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2012.120034"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360611"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240523"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv047"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.751095"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/074823378900500509"},{"key":"e_1_2_9_65_1","unstructured":"NTP (US National Toxicology Program)(1993). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CAS No. 10034\u201096\u20105) in F344\/N Rats and B6C3F1 Mice (Feed Studies).NTP Technical Report Series 428 NIH Publication No. 94\u20103159: 1.https:\/\/ntp.niehs.nih.gov\/ntp\/htdocs\/lt_rpts\/tr428.pdf."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.08.004"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.11.007"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/118.6.764"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.suppl_9.2435S"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.3.747"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.3.457"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602260"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.1.133"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/54.2.295"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00916-E"},{"key":"e_1_2_9_76_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0002-8223(21)00072-9","volume":"82","author":"Gibson R. S.","year":"1983","journal-title":"J. Am. Diet. Assoc."},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002321"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.08.011"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-007-0407-7"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP168"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2008.06.002"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-015-4211-5"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02916815"},{"key":"e_1_2_9_82_3","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.46.46"},{"key":"e_1_2_9_83_1","first-page":"1629","volume":"47","author":"Eastman R. R.","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/annweh\/wxx091"},{"key":"e_1_2_9_85_1","first-page":"205","volume":"20","author":"Greger J. L.","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_9_86_1","first-page":"405","volume":"22","author":"Aschner J. L.","year":"2015","journal-title":"Issues Toxicol."},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093900"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12088"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100038786"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.47.68"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710102500287"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.01.004"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20737"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-2465-4"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-13-31"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307865"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.04.012"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.11.273"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/es203569f"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.08.013"},{"key":"e_1_2_9_98_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.12.003"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90775-3"},{"key":"e_1_2_9_100_1","unstructured":"BfR (Bundesinstitut f\u00fcr Risikobewertung (Federal Insitute for Risk Assessment))(2006). Use of Minerals in Foods \u2010 Toxicological and nutritional\u2010physiological aspects \u2010 Part II.BfR WissenschaftChapter16:277.http:\/\/www.bfr.bund.de\/cm\/350\/use_of_minerals_in_foods.pdf."},{"key":"e_1_2_9_101_1","author":"EVM (Expert Group on Vitamins and Minerals)","year":"2003","journal-title":"Scientific Report"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.05.004"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.01.016"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13030352"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516002580"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-017-0136-1"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00020-3"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2162-z"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(84)90216-4"},{"key":"e_1_2_9_109_2","first-page":"477","volume":"20","author":"Brenneman K. A.","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_9_109_3","first-page":"65","volume":"2","author":"Deskin R.","year":"1981","journal-title":"Neurotoxicology"},{"key":"e_1_2_9_109_4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(200005\/06)20:3<179::AID-JAT631>3.0.CO;2-C"},{"key":"e_1_2_9_109_5","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(91)90051-8"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp220"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20485"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2004.12.046"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(03)00101-1"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.12.019"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.07.001"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-016-9924-6"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP258"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.09.001"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1997.0197"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.10.001"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(80)90095-8"},{"key":"e_1_2_9_121_1","first-page":"240","volume":"18","author":"Murthy R. C.","year":"1980","journal-title":"Exp. Pathol."},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.04.003"},{"key":"e_1_2_9_123_1","unstructured":"WHO (World Health Organization)(2011). Guidelines for Drinking\u2010water Quality. Fourth Edition.http:\/\/www.who.int\/water_sanitation_health\/publications\/2011\/dwq_guidelines\/en\/."},{"key":"e_1_2_9_124_1","first-page":"41","volume":"1","author":"Couper J.","year":"1837","journal-title":"Br. Ann. Med. Pharmacol."},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120707519"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv099"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.889690"},{"key":"e_1_2_9_126_2","first-page":"865319","volume":"2011","author":"Sikk K.","year":"2011","journal-title":"Parkinsons Dis."},{"key":"e_1_2_9_126_3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072488"},{"key":"e_1_2_9_127_1","unstructured":"SCF (European Commission: Scientific Committee on Food)(2000). Opinion of the Scientific Committee on Food on the tolerable upper intake level of manganese (expressed on 19 October 2000). SCF\/CS\/NUT\/UPPLEV\/21 Final.https:\/\/ec.europa.eu\/food\/sites\/food\/files\/safety\/docs\/sci-com_scf_out80f_en.pdf."},{"key":"e_1_2_9_128_1","first-page":"119","volume":"22","author":"Dorman D. C.","year":"2015","journal-title":"Issues Toxicol."},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.698"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-016-0174-4"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-016-0108-x"},{"key":"e_1_2_9_132_1","first-page":"524","volume":"22","author":"Lucchini R.","year":"2015","journal-title":"Issues Toxicol."},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000253939.06166.7e"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.03.003"},{"key":"e_1_2_9_135_1","first-page":"216","volume":"28","author":"He P.","year":"1994","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"e_1_2_9_135_2","first-page":"156","volume":"29","author":"Zhang G.","year":"1995","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003397"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2011.12.002"},{"key":"e_1_2_9_136_3","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8030"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307918"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.08.015"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.07.024"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10051"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2015.03.008"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074119"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1989.9935883"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100039482"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/164.2.85"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0308"},{"key":"e_1_2_9_147_1","first-page":"270","volume":"18","author":"Malvasi A.","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-012-0307-x"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181e960ab"},{"key":"e_1_2_9_148_3","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181e9e120"},{"key":"e_1_2_9_148_4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199907)10:1<15::AID-JMRI3>3.0.CO;2-X"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880040620"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810393962"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10421"},{"key":"e_1_2_9_150_3","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110613"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1258\/000456306776865151"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2016.698"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563658608990461"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.07.010"},{"key":"e_1_2_9_155_1","first-page":"145","volume":"18","author":"Kawamura R.","year":"1941","journal-title":"Kitasato Arch. Exp. Med."},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-6687-0"},{"key":"e_1_2_9_156_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569543.2018.1486859"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.11.003"},{"key":"e_1_2_9_157_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-017-0098-x"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2548792"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2tx20064c"},{"key":"e_1_2_9_159_2","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-14-23"},{"key":"e_1_2_9_159_3","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12040"},{"key":"e_1_2_9_159_4","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1581608"},{"key":"e_1_2_9_160_1","doi-asserted-by":"crossref","unstructured":"MRI (Max Rubner\u2010Institut \u2010 Bundesforschungsinstitut f\u00fcr Ern\u00e4hrung und Lebensmittel (Federal Research Institute of Nutrition and Food))(2008). Nationale Verzehrsstudie II (NVS II).Ergebnisbericht Teil 1 und 2.https:\/\/www.mri.bund.de\/de\/institute\/ernaehrungsverhalten\/forschungsprojekte\/nvsII\/.","DOI":"10.1007\/s12082-008-0148-1"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2016.1189770"},{"key":"e_1_2_9_162_1","unstructured":"EFSA (European Food Safety Authority) EFSA Supporting Publications2015 2015:EN\u2010804. p. 90."},{"key":"e_1_2_9_163_1","unstructured":"Central Science Laboratory Proficiency Testing Group(2002). FAPAS (Food Analysis Performance Assessment Scheme) \u2010 Protocol for the Organisation and Analysis of Data.http:\/\/sid.gsi.co.jp\/csl\/fapas\/fapas_protocol_6th_ed.pdf\u2010 accessed: 2018\u201008\u201001."},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1039\/b103812p"},{"key":"e_1_2_9_165_1","first-page":"44","volume":"53","author":"Krems C.","year":"2006","journal-title":"Ern\u00e4hrungs Umschau"},{"key":"e_1_2_9_166_1","author":"De Boer W. J. G. P.","year":"2016","journal-title":"MCRA 82 a Web\u2010Based Program for Monte Carlo Risk Assessment Reference Manual"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2010.496794"},{"key":"e_1_2_9_168_1","unstructured":"ANSES (Agence Nationale de S\u00e9curit\u00e9 Sanitaire de l'Alimentation de l'Environnement et du Travail (French Agency for Food Environmental and Occupational Health and Safety)) (2011). Second French Total Diet Study (TDS 2) Report 1. Inorganic contaminants minerals persistent organic pollutants mycotoxins and phytoestrogens. ANSES Opinion.ANSES Scientific Publication.https:\/\/www.anses.fr\/en\/content\/second-french-total-diet-study-tds-2-report-1-inorganic-contaminants-minerals-persistent."},{"key":"e_1_2_9_169_1","unstructured":"FSANZ (Food Standards Australia New Zealand)(2011). The 23rd Australian Total Diet Study.https:\/\/www.foodstandards.gov.au\/publications\/documents\/FSANZ%2023rd%20ATDS_v8_.pdf."},{"key":"e_1_2_9_170_1","first-page":"748","volume":"32","author":"Perello G.","year":"2015","journal-title":"Food Addit. Contam. Part A"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2012.2579"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/1054-139X(95)00133-D"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.3.421"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2450"},{"key":"e_1_2_9_175_1","unstructured":"WHO (World Health Organization)(2005).Total Diet Studies: a recipe for safer food: GEMS\/Food.http:\/\/www.who.int\/foodsafety\/chem\/TDS_recipe_2005_en.pdf."},{"key":"e_1_2_9_176_1","first-page":"205","volume":"6","author":"Willers J.","year":"2015","journal-title":"Food Nutr. Sci."},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516000544"},{"key":"e_1_2_9_178_1","unstructured":"ANSES (Agence Nationale de S\u00e9curit\u00e9 Sanitaire de l'Alimentation de l'Environnement et du Travail (French Agency for Food Environmental and Occupational Health and Safety)) (2016). Infant Total Diet Study (iTDS) Report 1. ANSES Opinion.ANSES Scientific Publication."},{"key":"e_1_2_9_179_1","first-page":"346","volume":"56","author":"Brechthold A.","year":"2009","journal-title":"Ern\u00e4hrungsumschau"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030110071354"},{"key":"e_1_2_9_181_1","unstructured":"EFSA (European Food Safety Authority: Scientific Panel on Dietetic Products Nutrition and Allergies (NDA))2006. Tolerable upper intake levels for vitamins and minerals."},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(66)90094-4"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19820110"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1080\/026520399283876"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(83)90110-2"},{"key":"e_1_2_9_186_1","first-page":"1","volume":"1114","author":"EFSA (European Food Safety Authority: Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS))","year":"2009","journal-title":"EFSA J."},{"key":"e_1_2_9_187_1","unstructured":"WHO (World Health Organization)(2004). Guidelines for Drinking\u2010water Quality. Third Edition.http:\/\/www.who.int\/water_sanitation_health\/publications\/gdwq3\/en\/."},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104693"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030500135367"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201900065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201900065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.201900065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201900065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:32:26Z","timestamp":1693963946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201900065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":240,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/mnfr.201900065"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201900065","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900065"}}